FGFR3 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	RPL8	ribosomal protein L8	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	(S)-3-phenyllactic acid Anisomycin Puromycin
Novel	RPS6KA3	ribosomal protein S6 kinase A3	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Acetylsalicylic acid Fostamatinib	Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
Novel	SH2B1	SH2B adaptor protein 1	Factors involved in megakaryocyte development and platelet production
Novel	SLC25A6	solute carrier family 25 member 6	Mitochondrial protein import Mitochondrial protein import Influenza Virus Induced Apoptosis Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Mitochondrial protein degradation	Clodronic acid Etidronic acid
Novel	SMG7	SMG7 nonsense mediated mRNA decay factor	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Novel	SRPK2	SRSF protein kinase 2	Maturation of nucleoprotein	Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
Novel	STAT1	signal transducer and activator of transcription 1	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
Novel	STAT3	signal transducer and activator of transcription 3	Interleukin-6 signaling BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signalling to STAT3 Signaling by ALK Senescence-Associated Secretory Phenotype (SASP) Signaling by Leptin POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Association of TriC/CCT with target proteins during biosynthesis Transcriptional regulation of pluripotent stem cells Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling PTK6 Activates STAT3 PTK6 Activates STAT3 Interleukin-20 family signaling MET activates STAT3 MET activates STAT3 Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-37 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-21 signaling Transcriptional regulation of granulopoiesis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT3 nuclear events downstream of ALK signaling Inactivation of CSF3 (G-CSF) signaling Cytoprotection by HMOX1 Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling PKR-mediated signaling Regulation of PD-L1(CD274) transcription	ENMD-1198 OPB-111077	Oral cancer Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Novel	STK32B	serine/threonine kinase 32B
	ADD1	adducin 1	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
	ANOS1	anosmin 1	FGFR1c ligand binding and activation Negative regulation of FGFR1 signaling		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
	ATF3	activating transcription factor 3	ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency Regulation of PD-L1(CD274) transcription	Pseudoephedrine
	BORA	BORA aurora kinase A activator	Regulation of PLK1 Activity at G2/M Transition Cyclin A/B1/B2 associated events during G2/M transition
	C6orf47	chromosome 6 open reading frame 47
	CCDC17	coiled-coil domain containing 17
	CEP126	centrosomal protein 126
	CHGB	chromogranin B	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
	CTSK	cathepsin K	Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE Balicatib MIV-711	Pycnodysostosis
	EPHA4	EPH receptor A4	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells Somitogenesis	Fostamatinib

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