APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
EIF2B2	eukaryotic translation initiation factor 2B subunit beta	Recycling of eIF2:GDP		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
EIF2B5	eukaryotic translation initiation factor 2B subunit epsilon	Recycling of eIF2:GDP		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
EIF2S2	eukaryotic translation initiation factor 2 subunit beta	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
EIF3F	eukaryotic translation initiation factor 3 subunit F	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Quercetin
EIF3G	eukaryotic translation initiation factor 3 subunit G	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF3M	eukaryotic translation initiation factor 3 subunit M	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4E	eukaryotic translation initiation factor 4E	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	7-methyl-GpppA 7-methyl-7,8-dihydroguanosine-5'-diphosphate 7-methyl-guanosine-5'-triphosphate LY2275796 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
EIF4E2	eukaryotic translation initiation factor 4E family member 2	ISG15 antiviral mechanism
EIF5	eukaryotic translation initiation factor 5	Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF6	eukaryotic translation initiation factor 6		Copper
ELF2	E74 like ETS transcription factor 2	RUNX1 regulates transcription of genes involved in BCR signaling
ELK1	ETS transcription factor ELK1	ERK/MAPK targets NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling
ELK3	ETS transcription factor ELK3
EMC8	ER membrane protein complex subunit 8
EME1	essential meiotic structure-specific endonuclease 1	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
EMG1	EMG1 N1-specific pseudouridine methyltransferase	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol		Bowen-Conradi syndrome (BCS)
ENKD1	enkurin domain containing 1
ENO3	enolase 3	Glycolysis Gluconeogenesis	2-phospho-D-glyceric acid Phosphoenolpyruvate 2-Phosphoglycolic Acid Phosphonoacetohydroxamic Acid
ENTR1	endosome associated trafficking regulator 1
ENY2	ENY2 transcription and export complex 2 subunit	HATs acetylate histones

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