OGT - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SERPINH1	serpin family H member 1	Collagen biosynthesis and modifying enzymes
SETD7	SET domain containing 7, histone lysine methyltransferase	PKMTs methylate histone lysines	S-adenosyl-L-homocysteine
SF1	splicing factor 1	mRNA Splicing - Major Pathway	Artenimol
SF3A2	splicing factor 3a subunit 2	mRNA Splicing - Major Pathway	Copper
SF3A3	splicing factor 3a subunit 3	mRNA Splicing - Major Pathway	Phenethyl Isothiocyanate
SF3B4	splicing factor 3b subunit 4	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
SFPQ	splicing factor proline and glutamine rich	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis	Copper Artenimol
SGSH	N-sulfoglucosamine sulfohydrolase	HS-GAG degradation MPS IIIA - Sanfilippo syndrome A		Mucopolysaccharidosis type III (MPS3), including: Sanfilippo A syndrome (MPS3A); Sanfilippo B syndrome (MPS3B); Sanfilippo C syndrome (MPS3C); Sanfilippo D syndrome (MPS3D)
SH3GLB2	SH3 domain containing GRB2 like, endophilin B2
SHMT2	serine hydroxymethyltransferase 2	Metabolism of folate and pterines RHOG GTPase cycle Mitochondrial protein degradation	Pyridoxal phosphate Tetrahydrofolic acid Glycine Artenimol
SHOC2	SHOC2 leucine rich repeat scaffold protein	RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
SIN3A	SIN3 transcription regulator family member A	SUMOylation of transcription cofactors Regulation of lipid metabolism by PPARalpha NoRC negatively regulates rRNA expression RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Loss of MECP2 binding ability to 5mC-DNA Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels MECP2 regulates transcription of neuronal ligands FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes STAT3 nuclear events downstream of ALK signaling Cytoprotection by HMOX1 Regulation of MITF-M-dependent genes involved in apoptosis Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Factors involved in megakaryocyte development and platelet production
SLIT2	slit guidance ligand 2	Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs Formation of the ureteric bud
SMARCD1	SWI/SNF related BAF chromatin remodeling complex subunit D1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SMARCD2	SWI/SNF related BAF chromatin remodeling complex subunit D2	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SMARCE1	SWI/SNF related BAF chromatin remodeling complex subunit E1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Phenethyl Isothiocyanate
SMPDL3B	sphingomyelin phosphodiesterase acid like 3B
SNAP91	synaptosome associated protein 91	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
SNRNP70	small nuclear ribonucleoprotein U1 subunit 70	mRNA Splicing - Major Pathway
SNW1	SNW domain containing 1	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm

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