APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
E2F8	E2F transcription factor 8	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
EAF1	ELL associated factor 1	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
EBF4	EBF family member 4
EBP	EBP cholestenol delta-isomerase	Cholesterol biosynthesis via desmosterol Cholesterol biosynthesis via lathosterol	Tamoxifen
ECH1	enoyl-CoA hydratase 1	Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation
ECHDC1	ethylmalonyl-CoA decarboxylase 1
ECHDC2	enoyl-CoA hydratase domain containing 2
ECI1	enoyl-CoA delta isomerase 1	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Mitochondrial protein degradation	Octanoyl-Coenzyme A Benzamidine
ECI2	enoyl-CoA delta isomerase 2		Myristic acid
ECSIT	ECSIT signaling integrator	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
EEF1B2	eukaryotic translation elongation factor 1 beta 2	Eukaryotic Translation Elongation
EEF1D	eukaryotic translation elongation factor 1 delta	Eukaryotic Translation Elongation
EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
EFHD2	EF-hand domain family member D2	RHOD GTPase cycle
EFS	embryonal Fyn-associated substrate
EGFR	epidermal growth factor receptor	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PLCG1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Respiratory syncytial virus (RSV) attachment and entry Developmental Lineage of Mammary Gland Myoepithelial Cells	Cetuximab Lidocaine Gefitinib Erlotinib Lapatinib Panitumumab Alvocidib IGN311 Matuzumab Vandetanib Rindopepimut Canertinib Pelitinib Varlitinib AV-412 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE PD-168393 Afatinib Osimertinib Necitumumab Foreskin keratinocyte (neonatal) Depatuxizumab mafodotin Icotinib Neratinib Dacomitinib Fostamatinib Poziotinib Zalutumumab Brigatinib Olmutinib Zanubrutinib Abivertinib Mobocertinib Almonertinib Amivantamab	Laryngeal cancer Cervical cancer Oral cancer Gastric cancer Choriocarcinoma Esophageal cancer Glioma Bladder cancer
EHF	ETS homologous factor
EIF1	eukaryotic translation initiation factor 1
EIF1AX	eukaryotic translation initiation factor 1A X-linked	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF2A	eukaryotic translation initiation factor 2A

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