UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NEDD4	NEDD4 E3 ubiquitin protein ligase	ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
NEDD4L	NEDD4 like E3 ubiquitin protein ligase	Budding and maturation of HIV virion Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Stimuli-sensing channels Antigen processing: Ubiquitination & Proteasome degradation
NEK8	NIMA related kinase 8			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
NEK9	NIMA related kinase 9	Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation	Fostamatinib
NEU1	neuraminidase 1	Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism	Oseltamivir Celecoxib Acetylsalicylic acid	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Sialidosis; Mucolipidosis I Galactosialidosis
NEURL3	neuralized E3 ubiquitin protein ligase 3
NFIA	nuclear factor I A	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
NFIC	nuclear factor I C	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
NFX1	nuclear transcription factor, X-box binding 1
NGLY1	N-glycanase 1	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
NHERF2	NHERF family PDZ scaffold protein 2
NIPSNAP1	nipsnap homolog 1
NIPSNAP2	nipsnap homolog 2	RHOH GTPase cycle RHOJ GTPase cycle
NOSIP	nitric oxide synthase interacting protein	NOSIP mediated eNOS trafficking
NPFFR1	neuropeptide FF receptor 1	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
NPLOC4	NPL4 homolog, ubiquitin recognition factor	Translesion Synthesis by POLH Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
NPM1	nucleophosmin 1	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation SARS-CoV-1-host interactions ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer PKR-mediated signaling	Artenimol
NPRL3	NPR3 like, GATOR1 complex subunit	Amino acids regulate mTORC1
NPTN	neuroplastin	GABA receptor activation
NR2F1	nuclear receptor subfamily 2 group F member 1	Nuclear Receptor transcription pathway	beta-Naphthoflavone

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