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SMARCC2 |
SWI/SNF related BAF chromatin remodeling complex subunit C2 |
- RMTs methylate histone arginines
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of the non-canonical BAF (ncBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
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SORCS3 |
sortilin related VPS10 domain containing receptor 3 |
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SOX3 |
SRY-box transcription factor 3 |
- Deactivation of the beta-catenin transactivating complex
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- Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
- Septo-optic dysplasia
- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
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SPEN |
spen family transcriptional repressor |
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SREBF1 |
sterol regulatory element binding transcription factor 1 |
- Cholesterol biosynthesis
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
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- Doconexent
- Omega-3-acid ethyl esters
- Omega-3 fatty acids
- Fish oil
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SREBF2 |
sterol regulatory element binding transcription factor 2 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Cholesterol biosynthesis
- PPARA activates gene expression
- Activation of gene expression by SREBF (SREBP)
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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ST6GALNAC6 |
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
- Sialic acid metabolism
- Lewis blood group biosynthesis
- Glycosphingolipid biosynthesis
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STAC2 |
SH3 and cysteine rich domain 2 |
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STAM2 |
signal transducing adaptor molecule 2 |
- EGFR downregulation
- Ub-specific processing proteases
- Negative regulation of MET activity
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- InlB-mediated entry of Listeria monocytogenes into host cell
- RHOU GTPase cycle
- Endosomal Sorting Complex Required For Transport (ESCRT)
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SUGP2 |
SURP and G-patch domain containing 2 |
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SUMO1 |
small ubiquitin like modifier 1 |
- SUMO is conjugated to E1 (UBA2:SAE1)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is proteolytically processed
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Formation of Incision Complex in GG-NER
- Regulation of IFNG signaling
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Postmitotic nuclear pore complex (NPC) reformation
- Maturation of nucleoprotein
- Maturation of nucleoprotein
- SUMOylation of nuclear envelope proteins
- PKR-mediated signaling
- Transcriptional and post-translational regulation of MITF-M expression and activity
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SUPT20H |
SPT20 homolog, SAGA complex component |
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SV2A |
synaptic vesicle glycoprotein 2A |
- Toxicity of botulinum toxin type D (botD)
- Toxicity of botulinum toxin type A (botA)
- Toxicity of botulinum toxin type F (botF)
- Toxicity of botulinum toxin type E (botE)
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- Levetiracetam
- Brivaracetam
- Seletracetam
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SYBU |
syntabulin |
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TBC1D5 |
TBC1 domain family member 5 |
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TBX15 |
T-box transcription factor 15 |
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TCAP |
titin-cap |
- Striated Muscle Contraction
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- Limb-girdle muscular dystrophy (LGMD)
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TCEANC |
transcription elongation factor A N-terminal and central domain containing |
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TCTA |
T cell leukemia translocation altered |
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TDP2 |
tyrosyl-DNA phosphodiesterase 2 |
- Nonhomologous End-Joining (NHEJ)
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