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ISL1 |
ISL LIM homeobox 1 |
- Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
- Regulation of expression of SLITs and ROBOs
- Cardiogenesis
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ITGB3BP |
integrin subunit beta 3 binding protein |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- NRIF signals cell death from the nucleus
- NRIF signals cell death from the nucleus
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Deposition of new CENPA-containing nucleosomes at the centromere
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
- Pre-NOTCH Transcription and Translation
- Oxidative Stress Induced Senescence
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated MAPK activation
- Activation of the AP-1 family of transcription factors
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- MAPK6/MAPK4 signaling
- TP53 Regulates Transcription of DNA Repair Genes
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Regulation of PTEN gene transcription
- Regulation of PTEN gene transcription
- Estrogen-dependent gene expression
- WNT5:FZD7-mediated leishmania damping
- Signaling by ALK fusions and activated point mutants
- Regulation of PD-L1(CD274) transcription
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- Adapalene
- Vinblastine
- Pseudoephedrine
- Irbesartan
- Arsenic trioxide
- LGD-1550
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JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Interleukin-4 and Interleukin-13 signaling
- NGF-stimulated transcription
- NGF-stimulated transcription
- Nuclear events stimulated by ALK signaling in cancer
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JUND |
JunD proto-oncogene, AP-1 transcription factor subunit |
- Estrogen-dependent gene expression
- NGF-stimulated transcription
- NGF-stimulated transcription
- Regulation of PD-L1(CD274) transcription
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KARS1 |
lysyl-tRNA synthetase 1 |
- Selenoamino acid metabolism
- Cytosolic tRNA aminoacylation
- Mitochondrial tRNA aminoacylation
- Transcriptional and post-translational regulation of MITF-M expression and activity
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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KAT5 |
lysine acetyltransferase 5 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- DNA Damage/Telomere Stress Induced Senescence
- HATs acetylate histones
- HDR through Single Strand Annealing (SSA)
- HDR through Homologous Recombination (HRR)
- Sensing of DNA Double Strand Breaks
- Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Resolution of D-loop Structures through Holliday Junction Intermediates
- Nonhomologous End-Joining (NHEJ)
- Homologous DNA Pairing and Strand Exchange
- Processing of DNA double-strand break ends
- Presynaptic phase of homologous DNA pairing and strand exchange
- Regulation of TP53 Activity through Phosphorylation
- G2/M DNA damage checkpoint
- Estrogen-dependent gene expression
- Defective homologous recombination repair (HRR) due to BRCA1 loss of function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
- Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
- Impaired BRCA2 binding to RAD51
- Impaired BRCA2 binding to PALB2
- Cardiogenesis
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- Coenzyme A
- S-Acetyl-Cysteine
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KATNA1 |
katanin catalytic subunit A1 |
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KDM5A |
lysine demethylase 5A |
- HDMs demethylate histones
- Chromatin modifications during the maternal to zygotic transition (MZT)
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KIF1A |
kinesin family member 1A |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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- Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
- Phosphoaminophosphonic Acid-Adenylate Ester
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KLF5 |
KLF transcription factor 5 |
- Transcriptional regulation of white adipocyte differentiation
- Transcriptional regulation of granulopoiesis
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KLK5 |
kallikrein related peptidase 5 |
- Formation of the cornified envelope
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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KLK9 |
kallikrein related peptidase 9 |
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KMT2D |
lysine methyltransferase 2D |
- Formation of the beta-catenin:TCF transactivating complex
- PKMTs methylate histone lysines
- Deactivation of the beta-catenin transactivating complex
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Formation of WDR5-containing histone-modifying complexes
- Epigenetic regulation of gene expression by MLL3 and MLL4 complexes
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
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KMT5B |
lysine methyltransferase 5B |
- PKMTs methylate histone lysines
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KRT10 |
keratin 10 |
- Keratinization
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
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- Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
- Ichthyosis with confetti; Congenital reticular ichthyosiform erythroderma; Ichthyosis variegata
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KRT18 |
keratin 18 |
- Keratinization
- Formation of the cornified envelope
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Alveolar Cells
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KRT19 |
keratin 19 |
- Keratinization
- Formation of the cornified envelope
- Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
- Developmental Lineage of Pancreatic Ductal Cells
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Alveolar Cells
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KRT8 |
keratin 8 |
- Keratinization
- Formation of the cornified envelope
- Developmental Lineage of Mammary Gland Luminal Epithelial Cells
- Developmental Lineage of Mammary Gland Alveolar Cells
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- Tenecteplase
- Lanoteplase
- Copper
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LARS1 |
leucyl-tRNA synthetase 1 |
- Selenoamino acid metabolism
- Cytosolic tRNA aminoacylation
- Transcriptional and post-translational regulation of MITF-M expression and activity
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