TP53 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
Novel	UBE2K	ubiquitin conjugating enzyme E2 K	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE2L3	ubiquitin conjugating enzyme E2 L3	PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling Regulation of necroptotic cell death Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE2M	ubiquitin conjugating enzyme E2 M	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE2N	ubiquitin conjugating enzyme E2 N	ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE2Q1	ubiquitin conjugating enzyme E2 Q1	Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE2V2	ubiquitin conjugating enzyme E2 V2	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Novel	UBE3A	ubiquitin protein ligase E3A	Antigen processing: Ubiquitination & Proteasome degradation	Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
Novel	UBE4B	ubiquitination factor E4B
Novel	UFD1	ubiquitin recognition factor in ER associated degradation 1	Translesion Synthesis by POLH Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Novel	UFL1	UFM1 specific ligase 1	Antigen processing: Ubiquitination & Proteasome degradation
Novel	UHRF1	ubiquitin like with PHD and ring finger domains 1	DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)
Novel	UHRF2	ubiquitin like with PHD and ring finger domains 2	SUMOylation of transcription cofactors
Novel	UIMC1	ubiquitin interaction motif containing 1	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Novel	USP19	ubiquitin specific peptidase 19	Ub-specific processing proteases
Novel	USP21	ubiquitin specific peptidase 21	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Novel	USP24	ubiquitin specific peptidase 24	Ub-specific processing proteases
Novel	USP28	ubiquitin specific peptidase 28	Ub-specific processing proteases
Novel	USP3	ubiquitin specific peptidase 3	Ub-specific processing proteases
Novel	USP42	ubiquitin specific peptidase 42	Ub-specific processing proteases
Novel	USP49	ubiquitin specific peptidase 49	Ub-specific processing proteases

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