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UBE2I |
ubiquitin conjugating enzyme E2 I |
- Meiotic synapsis
- Vitamin D (calciferol) metabolism
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMO is transferred from E1 to E2 (UBE2I, UBC9)
- SUMOylation of DNA damage response and repair proteins
- SUMOylation of transcription factors
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- SUMOylation of transcription cofactors
- SUMOylation of transcription cofactors
- SUMOylation of SUMOylation proteins
- SUMOylation of intracellular receptors
- SUMOylation of intracellular receptors
- SUMOylation of chromatin organization proteins
- SUMOylation of chromatin organization proteins
- SUMOylation of RNA binding proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA replication proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of DNA methylation proteins
- SUMOylation of immune response proteins
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Postmitotic nuclear pore complex (NPC) reformation
- Maturation of nucleoprotein
- Maturation of nucleoprotein
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- SUMOylation of nuclear envelope proteins
- PKR-mediated signaling
- Regulation of endogenous retroelements by KRAB-ZFP proteins
- Transcriptional and post-translational regulation of MITF-M expression and activity
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UBE2K |
ubiquitin conjugating enzyme E2 K |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Negative regulators of DDX58/IFIH1 signaling
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2L3 |
ubiquitin conjugating enzyme E2 L3 |
- PINK1-PRKN Mediated Mitophagy
- Regulation of TNFR1 signaling
- Regulation of necroptotic cell death
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2M |
ubiquitin conjugating enzyme E2 M |
- TGF-beta receptor signaling activates SMADs
- Dectin-1 mediated noncanonical NF-kB signaling
- NIK-->noncanonical NF-kB signaling
- Neddylation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2N |
ubiquitin conjugating enzyme E2 N |
- ISG15 antiviral mechanism
- NOD1/2 Signaling Pathway
- TICAM1, RIP1-mediated IKK complex recruitment
- Downstream TCR signaling
- FCERI mediated NF-kB activation
- TAK1-dependent IKK and NF-kappa-B activation
- activated TAK1 mediates p38 MAPK activation
- JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
- PINK1-PRKN Mediated Mitophagy
- CLEC7A (Dectin-1) signaling
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Interleukin-1 signaling
- IRAK1 recruits IKK complex
- IKK complex recruitment mediated by RIP1
- Aggrephagy
- Aggrephagy
- SARS-CoV-2 activates/modulates innate and adaptive immune responses
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2Q1 |
ubiquitin conjugating enzyme E2 Q1 |
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2V2 |
ubiquitin conjugating enzyme E2 V2 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- Formation of Incision Complex in GG-NER
- G2/M DNA damage checkpoint
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE3A |
ubiquitin protein ligase E3A |
- Antigen processing: Ubiquitination & Proteasome degradation
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- Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
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UBE4B |
ubiquitination factor E4B |
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UFD1 |
ubiquitin recognition factor in ER associated degradation 1 |
- Translesion Synthesis by POLH
- Ub-specific processing proteases
- Neddylation
- KEAP1-NFE2L2 pathway
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
- Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
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UFL1 |
UFM1 specific ligase 1 |
- Antigen processing: Ubiquitination & Proteasome degradation
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UHRF1 |
ubiquitin like with PHD and ring finger domains 1 |
- DNA methylation
- Chromatin modifications during the maternal to zygotic transition (MZT)
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UHRF2 |
ubiquitin like with PHD and ring finger domains 2 |
- SUMOylation of transcription cofactors
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UIMC1 |
ubiquitin interaction motif containing 1 |
- Metalloprotease DUBs
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
- Nonhomologous End-Joining (NHEJ)
- Processing of DNA double-strand break ends
- G2/M DNA damage checkpoint
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USP19 |
ubiquitin specific peptidase 19 |
- Ub-specific processing proteases
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USP21 |
ubiquitin specific peptidase 21 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NF-kappa-B signaling pathway
- Ub-specific processing proteases
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USP24 |
ubiquitin specific peptidase 24 |
- Ub-specific processing proteases
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USP28 |
ubiquitin specific peptidase 28 |
- Ub-specific processing proteases
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USP3 |
ubiquitin specific peptidase 3 |
- Ub-specific processing proteases
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USP42 |
ubiquitin specific peptidase 42 |
- Ub-specific processing proteases
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