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SSTR3 |
somatostatin receptor 3 |
- Peptide ligand-binding receptors
- G alpha (i) signalling events
- BBSome-mediated cargo-targeting to cilium
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- Pasireotide
- Somatostatin
- Lutetium Lu 177 dotatate
- Edotreotide gallium Ga-68
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STUB1 |
STIP1 homology and U-box containing protein 1 |
- Downregulation of TGF-beta receptor signaling
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- Regulation of necroptotic cell death
- Downregulation of ERBB2 signaling
- Regulation of RUNX2 expression and activity
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SYNE2 |
spectrin repeat containing nuclear envelope protein 2 |
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- Emery-Dreifuss muscular dystrophy
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TAX1BP3 |
Tax1 binding protein 3 |
- RHO GTPases Activate Rhotekin and Rhophilins
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TBL1X |
transducin beta like 1 X-linked |
- BMAL1:CLOCK,NPAS2 activates circadian expression
- PPARA activates gene expression
- PPARA activates gene expression
- NOTCH1 Intracellular Domain Regulates Transcription
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HDACs deacetylate histones
- Notch-HLH transcription pathway
- Transcriptional regulation of white adipocyte differentiation
- Regulation of lipid metabolism by PPARalpha
- Loss of MECP2 binding ability to the NCoR/SMRT complex
- Regulation of MECP2 expression and activity
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- HCMV Early Events
- Cytoprotection by HMOX1
- Heme signaling
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
- Expression of BMAL (ARNTL), CLOCK, and NPAS2
- RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
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TCF3 |
transcription factor 3 |
- Myogenesis
- Myogenesis
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Negative Regulation of CDH1 Gene Transcription
- TGFBR3 expression
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- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
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TCF4 |
transcription factor 4 |
- Myogenesis
- Myogenesis
- TGFBR3 expression
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- Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
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TCF7L1 |
transcription factor 7 like 1 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Deactivation of the beta-catenin transactivating complex
- Ca2+ pathway
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- Repression of WNT target genes
- Repression of WNT target genes
- RUNX3 regulates WNT signaling
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Specification of the neural plate border
- Regulation of PD-L1(CD274) transcription
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TCF7L2 |
transcription factor 7 like 2 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Deactivation of the beta-catenin transactivating complex
- Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
- Ca2+ pathway
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- Repression of WNT target genes
- Repression of WNT target genes
- Signaling by TCF7L2 mutants
- Transcriptional Regulation by VENTX
- RUNX3 regulates WNT signaling
- Formation of definitive endoderm
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Regulation of PD-L1(CD274) transcription
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- Type II diabetes mellitus
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TFAP2A |
transcription factor AP-2 alpha |
- Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- Negative regulation of activity of TFAP2 (AP-2) family transcription factors
- TFAP2 (AP-2) family regulates transcription of other transcription factors
- Activation of the TFAP2 (AP-2) family of transcription factors
- TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
- Positive Regulation of CDH1 Gene Transcription
- Regulation of MITF-M-dependent genes involved in pigmentation
- Specification of the neural plate border
- Specification of the neural plate border
- Developmental Lineage of Mammary Stem Cells
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- Branchiooculofacial syndrome (BOFS)
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TGFBR1 |
transforming growth factor beta receptor 1 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- Ub-specific processing proteases
- TGFBR3 regulates TGF-beta signaling
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- 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
- Naphthyridine Inhibitor
- 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
- N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
- 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
- N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
- Fostamatinib
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- Loeys-Dietz syndrome (LDS)
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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TGFBR2 |
transforming growth factor beta receptor 2 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- TGFBR3 regulates TGF-beta signaling
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- Foreskin fibroblast (neonatal)
- Foreskin keratinocyte (neonatal)
- Fostamatinib
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- Loeys-Dietz syndrome (LDS)
- Colorectal cancer
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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TJP1 |
tight junction protein 1 |
- Regulation of gap junction activity
- Regulation of gap junction activity
- Signaling by Hippo
- Apoptotic cleavage of cell adhesion proteins
- RUNX1 regulates expression of components of tight junctions
- SARS-CoV-2 targets PDZ proteins in cell-cell junction
- SARS-CoV-2 targets PDZ proteins in cell-cell junction
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TLE1 |
TLE family member 1, transcriptional corepressor |
- Formation of the beta-catenin:TCF transactivating complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Deactivation of the beta-catenin transactivating complex
- Repression of WNT target genes
- Repression of WNT target genes
- Negative Regulation of CDH1 Gene Transcription
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TRIM26 |
tripartite motif containing 26 |
- Interferon gamma signaling
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TRIM33 |
tripartite motif containing 33 |
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Germ layer formation at gastrulation
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TRIM55 |
tripartite motif containing 55 |
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TRIM63 |
tripartite motif containing 63 |
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Antigen processing: Ubiquitination & Proteasome degradation
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TRIP10 |
thyroid hormone receptor interactor 10 |
- Clathrin-mediated endocytosis
- RHOQ GTPase cycle
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TRRAP |
transformation/transcription domain associated protein |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- HATs acetylate histones
- Ub-specific processing proteases
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