AR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NISCH	nischarin	RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	Tizanidine Agmatine Moxonidine Tepotinib
NLRP10	NLR family pyrin domain containing 10
NONO	non-POU domain containing octamer binding
NR0B1	nuclear receptor subfamily 0 group B member 1		Dexamethasone Dexamethasone acetate	Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
NR0B2	nuclear receptor subfamily 0 group B member 2	Nuclear Receptor transcription pathway
NR2C1	nuclear receptor subfamily 2 group C member 1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
NR2C2	nuclear receptor subfamily 2 group C member 2	Nuclear Receptor transcription pathway
NR3C1	nuclear receptor subfamily 3 group C member 1	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors PTK6 Expression Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Potential therapeutics for SARS Regulation of NPAS4 gene transcription	Flunisolide Diflorasone Alclometasone Medrysone Amcinonide Fluorometholone Megestrol acetate Levonorgestrel Beclomethasone dipropionate Progesterone Spironolactone Betamethasone Desoximetasone Fluticasone propionate Fluocinolone acetonide Ulobetasol Triamcinolone Prednisone Flumethasone Fludrocortisone Norethisterone Hydrocortisone Mometasone Hydrocortamate Mifepristone Clocortolone Flurandrenolide Prednisolone Loteprednol etabonate Rimexolone Methylprednisolone Clobetasol propionate Fluocinonide Prednicarbate Fluoxymesterone Budesonide Dexamethasone Desonide Cortisone acetate Paramethasone Drospirenone Ciclesonide Hexane-1,6-Diol Aldosterone ORG-34517 Difluprednate Ulipristal Fluticasone furoate Tixocortol Difluocortolone Gestrinone Deflazacort Onapristone Cortivazol Clobetasone Fluticasone Mometasone furoate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Segesterone acetate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate Prednisolone acetate	46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
NR3C2	nuclear receptor subfamily 3 group C member 2	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors	Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Stanolone acetate Finerenone	Hypertension exacerbated in pregnancy Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
NR5A1	nuclear receptor subfamily 5 group A member 1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation	(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol	Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
NRIP1	nuclear receptor interacting protein 1	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
NSD1	nuclear receptor binding SET domain protein 1	PKMTs methylate histone lysines		Sotos syndrome and Weaver syndrome Beckwith-Wiedemann syndrome
NSD2	nuclear receptor binding SET domain protein 2	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint		Multiple myeloma
PA2G4	proliferation-associated 2G4	Neutrophil degranulation
PAK6	p21 (RAC1) activated kinase 6	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Fostamatinib
PELP1	proline, glutamate and leucine rich protein 1	Major pathway of rRNA processing in the nucleolus and cytosol PTK6 Expression
PGK1	phosphoglycerate kinase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol	Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
PIAS1	protein inhibitor of activated STAT 1	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
PIAS2	protein inhibitor of activated STAT 2	Activation of anterior HOX genes in hindbrain development during early embryogenesis
PIAS3	protein inhibitor of activated STAT 3	SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER

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