APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
COL4A1	collagen type IV alpha 1 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells		Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) Brain small vessel disease with Axenfeld-Rieger anomaly Porencephaly
COL4A2	collagen type IV alpha 2 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
COL4A3	collagen type IV alpha 3 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
COL4A5	collagen type IV alpha 5 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs Attachment of bacteria to epithelial cells		Alport syndrome
COL4A6	collagen type IV alpha 6 chain	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Collagen chain trimerization Attachment of bacteria to epithelial cells
COLEC12	collectin subfamily member 12	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
COMMD2	COMM domain containing 2	Neddylation
COPB1	coat protein complex I subunit beta 1	Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
COPS5	COP9 signalosome subunit 5	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation GSK3B-mediated proteasomal degradation of PD-L1(CD274)
COPS7B	COP9 signalosome subunit 7B	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
COPZ1	coat protein complex I subunit zeta 1	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
COQ6	coenzyme Q6, monooxygenase	Ubiquinol biosynthesis
COX4I1	cytochrome c oxidase subunit 4I1	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly	Cholic Acid N-Formylmethionine
COX4I2	cytochrome c oxidase subunit 4I2	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly		Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis
COX6A2	cytochrome c oxidase subunit 6A2	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	Cholic Acid N-Formylmethionine
COXFA4	cytochrome c oxidase associated subunit FA4	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly	NADH
CPEB1	cytoplasmic polyadenylation element binding protein 1
CPED1	cadherin like and PC-esterase domain containing 1
CPLX2	complexin 2
CRACR2B	calcium release activated channel regulator 2B

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