Search Results for: APP

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
CLIC3 chloride intracellular channel 3
CLIP4 CAP-Gly domain containing linker protein family member 4
CLK3 CDC like kinase 3
  • K-00546
  • ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
  • Fostamatinib
CLP1 cleavage factor polyribonucleotide kinase subunit 1
  • tRNA processing in the nucleus
  • mRNA 3'-end processing
  • Processing of Capped Intron-Containing Pre-mRNA
  • RNA Polymerase II Transcription Termination
  • Processing of Intronless Pre-mRNAs
CLU clusterin
  • Platelet degranulation
  • Terminal pathway of complement
  • Antimicrobial peptides
  • Regulation of Complement cascade
  • Zinc
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
CLUAP1 clusterin associated protein 1
  • Intraflagellar transport
  • Intraflagellar transport
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
  • Sialic acid metabolism
  • Cytidine-5'-Monophosphate-5-N-Acetylneuraminic Acid
CMTM2 CKLF like MARVEL transmembrane domain containing 2
CMTM3 CKLF like MARVEL transmembrane domain containing 3
CNDP1 carnosine dipeptidase 1
CNOT7 CCR4-NOT transcription complex subunit 7
  • Deadenylation of mRNA
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
  • M-decay: degradation of maternal mRNAs by maternally stored factors
CNPY2 canopy FGF signaling regulator 2
COA5 cytochrome c oxidase assembly factor 5
  • Complex IV assembly
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
COASY Coenzyme A synthase
  • Coenzyme A biosynthesis
COIL coilin
COL11A1 collagen type XI alpha 1 chain
  • Collagen degradation
  • Collagen degradation
  • Collagen biosynthesis and modifying enzymes
  • Assembly of collagen fibrils and other multimeric structures
  • Non-integrin membrane-ECM interactions
  • MET activates PTK2 signaling
  • Collagen chain trimerization
  • Developmental Lineage of Pancreatic Ductal Cells
  • Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome
  • Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
COL14A1 collagen type XIV alpha 1 chain
  • Collagen degradation
  • Collagen biosynthesis and modifying enzymes
  • Assembly of collagen fibrils and other multimeric structures
  • Collagen chain trimerization
COL18A1 collagen type XVIII alpha 1 chain
  • Collagen degradation
  • Activation of Matrix Metalloproteinases
  • Collagen biosynthesis and modifying enzymes
  • Assembly of collagen fibrils and other multimeric structures
  • Integrin cell surface interactions
  • Laminin interactions
  • Collagen chain trimerization
  • Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
  • Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
COL1A2 collagen type I alpha 2 chain
  • GPVI-mediated activation cascade
  • Collagen degradation
  • Collagen degradation
  • Fibronectin matrix formation
  • Collagen biosynthesis and modifying enzymes
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • Assembly of collagen fibrils and other multimeric structures
  • Cell surface interactions at the vascular wall
  • Integrin cell surface interactions
  • Integrin cell surface interactions
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Anchoring fibril formation
  • Crosslinking of collagen fibrils
  • Syndecan interactions
  • Non-integrin membrane-ECM interactions
  • ECM proteoglycans
  • ECM proteoglycans
  • Scavenging by Class A Receptors
  • GP1b-IX-V activation signalling
  • Interleukin-4 and Interleukin-13 signaling
  • Platelet Adhesion to exposed collagen
  • Platelet Adhesion to exposed collagen
  • Platelet Aggregation (Plug Formation)
  • MET activates PTK2 signaling
  • Collagen chain trimerization
  • Enhanced cleavage of VWF variant by ADAMTS13
  • Enhanced binding of GP1BA variant to VWF multimer:collagen
  • Defective VWF cleavage by ADAMTS13 variant
  • Defective VWF binding to collagen type I
  • Defective binding of VWF variant to GPIb:IX:V
  • Developmental Lineage of Pancreatic Ductal Cells
  • Osteogenesis imperfecta
  • Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
COL25A1 collagen type XXV alpha 1 chain
  • Collagen degradation
  • Collagen biosynthesis and modifying enzymes
  • Collagen chain trimerization

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