MUC1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	C2	complement C2	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade		Systemic lupus erythematosus Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
Novel	C2CD2L	C2CD2 like
Novel	C3orf52	chromosome 3 open reading frame 52
Novel	CACNG1	calcium voltage-gated channel auxiliary subunit gamma 1		Ergocalciferol Enflurane Ibutilide Diltiazem Spironolactone Lercanidipine Nicardipine Verapamil Ethanol Fluspirilene Efonidipine Butamben Bioallethrin
Novel	CCDC167	coiled-coil domain containing 167
Novel	CD47	CD47 molecule	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Novel	CD53	CD53 molecule	Neutrophil degranulation
Novel	CD68	CD68 molecule	Neutrophil degranulation
Novel	CLDN19	claudin 19	Tight junction interactions
Novel	CLDN6	claudin 6	Tight junction interactions
Novel	CLDND2	claudin domain containing 2
Novel	CMTM7	CKLF like MARVEL transmembrane domain containing 7
Novel	COL8A2	collagen type VIII alpha 2 chain	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization		Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy Posterior polymorphous corneal dystrophy (PPCD)
Novel	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	CS-GAG biosynthesis
Novel	CTNNB1	catenin beta 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling Cardiogenesis Germ layer formation at gastrulation Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm Somitogenesis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Formation of the nephric duct CDH11 homotypic and heterotypic interactions Specification of the neural plate border High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription	Urea	Pilomatricoma; Epithelioma calcificans of Malherbe Gastric cancer Hepatocellular carcinoma Thyroid cancer Colorectal cancer Endometrial Cancer
Novel	CTNND1	catenin delta 1	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
Novel	CTSA	cathepsin A	MHC class II antigen presentation Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism		Galactosialidosis
Novel	CXCL16	C-X-C motif chemokine ligand 16	Chemokine receptors bind chemokines G alpha (i) signalling events
Novel	CXCL9	C-X-C motif chemokine ligand 9	Chemokine receptors bind chemokines G alpha (i) signalling events
Novel	CYB5B	cytochrome b5 type B	Sphingolipid de novo biosynthesis eNOS activation Phase I - Functionalization of compounds	Phenethyl Isothiocyanate

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