CHEK2 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	DBF4	DBF4-CDC7 kinase regulatory subunit	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Novel	DIRAS3	DIRAS family GTPase 3
Novel	E2F1	E2F transcription factor 1	Activation of NOXA and translocation to mitochondria Inhibition of replication initiation of damaged DNA by RB1/E2F1 Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest G2 Phase Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6 Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Novel	ELAVL1	ELAV like RNA binding protein 1	HuR (ELAVL1) binds and stabilizes mRNA
Novel	ENO1	enolase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Novel	ERCC6	ERCC excision repair 6, chromatin remodeling factor	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Novel	FHL1	four and a half LIM domains 1			X-linked myopathy with postural muscle atrophy (XMPMA) Scapuloperoneal myopathy (SPM) Reducing body myopathy (RBM) Emery-Dreifuss muscular dystrophy
Novel	FHL3	four and a half LIM domains 3
Novel	FOXM1	forkhead box M1	Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition Nuclear events stimulated by ALK signaling in cancer
Novel	FUS	FUS RNA binding protein	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA		Myxoid liposarcoma Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Novel	GNAS	GNAS complex locus	Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE	Pseudohypoparathyroidism Progressive osseous heteroplasia (POH) Fibrous dysplasia, polyostotic; Albright hereditary osteodystrophy
Novel	GRK3	G protein-coupled receptor kinase 3	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis	ATP
Novel	HMGN1	high mobility group nucleosome binding domain 1
Novel	HOXC6	homeobox C6
Novel	ITIH5	inter-alpha-trypsin inhibitor heavy chain 5
Novel	KLK7	kallikrein related peptidase 7	Degradation of the extracellular matrix Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Novel	KLK9	kallikrein related peptidase 9
Novel	KPNA2	karyopherin subunit alpha 2	CaMK IV-mediated phosphorylation of CREB ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Sensing of DNA Double Strand Breaks Estrogen-dependent gene expression SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses
Novel	LATS2	large tumor suppressor kinase 2	Signaling by Hippo
Novel	LYPD3	LY6/PLAUR domain containing 3	Post-translational modification: synthesis of GPI-anchored proteins

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