UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
IMPACT	impact RWD domain protein	Response of EIF2AK4 (GCN2) to amino acid deficiency
ING1	inhibitor of growth family member 1
INO80B-WBP1	INO80B-WBP1 readthrough (NMD candidate)
INPPL1	inositol polyphosphate phosphatase like 1	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
INTS14	integrator complex subunit 14	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
IQGAP3	IQ motif containing GTPase activating protein 3	RHO GTPases activate IQGAPs RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
IRS1	insulin receptor substrate 1	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling Signaling by LTK	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
ISX	intestine specific homeobox
ITCH	itchy E3 ubiquitin protein ligase	Downregulation of ERBB4 signaling NOD1/2 Signaling Pathway Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Degradation of GLI1 by the proteasome Hedgehog 'on' state Regulation of necroptotic cell death RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses Antigen processing: Ubiquitination & Proteasome degradation
ITGAV	integrin subunit alpha V	Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Antithymocyte immunoglobulin (rabbit) Levothyroxine PLN-74809
ITSN1	intersectin 1	NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
ITSN2	intersectin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOU GTPase cycle
JOSD1	Josephin domain containing 1	Josephin domain DUBs
JOSD2	Josephin domain containing 2	Josephin domain DUBs
JPH1	junctophilin 1
JUN	Jun proto-oncogene, AP-1 transcription factor subunit	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants Regulation of PD-L1(CD274) transcription	Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
KANK2	KN motif and ankyrin repeat domains 2
KATNAL2	katanin catalytic subunit A1 like 2
KCMF1	potassium channel modulatory factor 1	Neutrophil degranulation
KCTD10	potassium channel tetramerization domain containing 10

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