ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
EFEMP2	EGF-like fibulin extracellular matrix protein 2	Molecules associated with elastic fibres Molecules associated with elastic fibres		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
EHMT1	euchromatic histone lysine methyltransferase 1	Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
EIF1AY	eukaryotic translation initiation factor 1A Y-linked
EIF1B	eukaryotic translation initiation factor 1B
EIF3F	eukaryotic translation initiation factor 3 subunit F	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Quercetin
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1
ELP5	elongator acetyltransferase complex subunit 5	HATs acetylate histones
EML3	EMAP like 3
ENTPD6	ectonucleoside triphosphate diphosphohydrolase 6	Phosphate bond hydrolysis by NTPDase proteins
EPN2	epsin 2	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
ESRP1	epithelial splicing regulatory protein 1	Signaling by BRAF and RAF1 fusions FGFR2 alternative splicing
ESRRA	estrogen related receptor alpha	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone
ETV4	ETS variant transcription factor 4	MAPK6/MAPK4 signaling		Prostate cancer Ewing's sarcoma
EXTL3	exostosin like glycosyltransferase 3	HS-GAG biosynthesis XBP1(S) activates chaperone genes
FAM153B	protein FAM153B
FAM168A	family with sequence similarity 168 member A
FAM193B	family with sequence similarity 193 member B
FAR1	fatty acyl-CoA reductase 1	Wax biosynthesis
FAT4	FAT atypical cadherin 4
FDPS	farnesyl diphosphate synthase	Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Pamidronic acid Zoledronic acid Alendronic acid Ibandronate Risedronic acid Dimethylallyl Diphosphate Isopentyl Pyrophosphate Geranyl Diphosphate ISOPENTENYL PYROPHOSPHATE Incadronic acid Minodronic acid Farnesyl diphosphate Geranylgeranyl diphosphate

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