ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CNOT6L	CCR4-NOT transcription complex subunit 6 like	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
COIL	coilin
CPSF7	cleavage and polyadenylation specific factor 7	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
CREM	cAMP responsive element modulator
CRIP2	cysteine rich protein 2
CRK	CRK proto-oncogene, adaptor protein	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis
CRX	cone-rod homeobox			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
CRY2	cryptochrome circadian regulator 2	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
CST3	cystatin C	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
CUTC	cutC copper transporter	Ion transport by P-type ATPases
DAZ2	deleted in azoospermia 2
DAZAP2	DAZ associated protein 2
DCTN3	dynactin subunit 3	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
DHRSX	dehydrogenase/reductase X-linked	Synthesis of dolichyl-phosphate
DHX37	DEAH-box helicase 37	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
DIXDC1	DIX domain containing 1
DMPK	DM1 protein kinase	Ion homeostasis	Bisindolylmaleimide VIII	Myotonic dystrophy (DM)
DNAJA3	DnaJ heat shock protein family (Hsp40) member A3
DOCK5	dedicator of cytokinesis 5	RAC1 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
DZIP3	DAZ interacting zinc finger protein 3	Antigen processing: Ubiquitination & Proteasome degradation

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