EGFR - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SH2B3	SH2B adaptor protein 3	Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production	Pazopanib	Type I diabetes mellitus
SH2D1A	SH2 domain containing 1A	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
SH2D1B	SH2 domain containing 1B	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SH2D2A	SH2 domain containing 2A	VEGFA-VEGFR2 Pathway
SH2D3A	SH2 domain containing 3A
SH2D3C	SH2 domain containing 3C
SH3BGRL3	SH3 domain binding glutamate rich protein like 3
SH3GL3	SH3 domain containing GRB2 like 3, endophilin A3	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
SHB	SH2 domain containing adaptor protein B	VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway
SHC1	SHC adaptor protein 1	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells
SHC2	SHC adaptor protein 2	Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
SHC4	SHC adaptor protein 4
SHD	Src homology 2 domain containing transforming protein D
SHE	Src homology 2 domain containing E
SLA	Src like adaptor	Negative regulation of FLT3
SLA2	Src like adaptor 2	Negative regulation of FLT3
SLC3A2	solute carrier family 3 member 2	Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism
SLC9D1	solute carrier family 9 member D1
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation

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