|
|
SERTAD1 |
SERTA domain containing 1 |
|
|
|
|
|
SFRP4 |
secreted frizzled related protein 4 |
|
- Cyclothiazide
- Perindopril
|
|
|
|
SGK1 |
serum/glucocorticoid regulated kinase 1 |
- PIP3 activates AKT signaling
- Stimuli-sensing channels
- Regulation of TP53 Degradation
- Transcriptional Regulation by MECP2
- NGF-stimulated transcription
|
- Flavin mononucleotide
- [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid
- 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
|
|
|
|
SIT1 |
signaling threshold regulating transmembrane adaptor 1 |
|
|
|
|
|
SIVA1 |
SIVA1 apoptosis inducing factor |
|
- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
|
|
|
SIX2 |
SIX homeobox 2 |
- Formation of the ureteric bud
|
|
|
|
|
SLC4A1 |
solute carrier family 4 member 1 (Diego blood group) |
- Erythrocytes take up carbon dioxide and release oxygen
- Erythrocytes take up oxygen and release carbon dioxide
- Bicarbonate transporters
- Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
|
|
- Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
- Distal renal tubular acidosis (RTA type 1)
- Hereditary spherocytosis (SPH)
- Hereditary elliptocytosis (HE)
|
|
|
SMARCA4 |
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- Negative Regulation of CDH1 Gene Transcription
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the polybromo-BAF (pBAF) complex
- Formation of the embryonic stem cell BAF (esBAF) complex
- Formation of the non-canonical BAF (ncBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
|
|
|
|
|
SNRPA |
small nuclear ribonucleoprotein polypeptide A |
- mRNA Splicing - Major Pathway
|
|
|
|
|
SNRPB |
small nuclear ribonucleoprotein polypeptides B and B1 |
- SLBP independent Processing of Histone Pre-mRNAs
- snRNP Assembly
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- RNA Polymerase II Transcription Termination
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
- SARS-CoV-2 modulates host translation machinery
|
|
|
|
|
SOX3 |
SRY-box transcription factor 3 |
- Deactivation of the beta-catenin transactivating complex
|
|
- Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
- Septo-optic dysplasia
- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
|
|
|
SOX4 |
SRY-box transcription factor 4 |
- Deactivation of the beta-catenin transactivating complex
|
|
|
|
|
STK11 |
serine/threonine kinase 11 |
- AMPK inhibits chREBP transcriptional activation activity
- Energy dependent regulation of mTOR by LKB1-AMPK
- Regulation of TP53 Activity through Phosphorylation
- FOXO-mediated transcription of cell death genes
|
|
- Peutz-Jeghers syndrome
- Pancreatic cancer
|
|
|
TBRG1 |
transforming growth factor beta regulator 1 |
|
|
|
|
|
TDRD7 |
tudor domain containing 7 |
|
|
|
|
|
TEAD2 |
TEA domain transcription factor 2 |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- RUNX3 regulates YAP1-mediated transcription
- Formation of axial mesoderm
- Regulation of PD-L1(CD274) transcription
|
|
|
|
|
TERT |
telomerase reverse transcriptase |
- Telomere Extension By Telomerase
- Formation of the beta-catenin:TCF transactivating complex
- Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
|
- Zidovudine
- Grn163l
- Tertomotide
|
- Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
|
|
|
TFDP1 |
transcription factor Dp-1 |
- Activation of NOXA and translocation to mitochondria
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by DREAM complex
- Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
- Activation of PUMA and translocation to mitochondria
- G0 and Early G1
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
- Cyclin E associated events during G1/S transition
- G1/S-Specific Transcription
- G1/S-Specific Transcription
- Cyclin D associated events in G1
- Cyclin A:Cdk2-associated events at S phase entry
- Transcriptional Regulation by E2F6
- Transcriptional regulation of granulopoiesis
- Transcriptional regulation of granulopoiesis
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
|
|
|
|
|
TGFB1 |
transforming growth factor beta 1 |
- Platelet degranulation
- Influenza Virus Induced Apoptosis
- Cell surface interactions at the vascular wall
- Molecules associated with elastic fibres
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Syndecan interactions
- ECM proteoglycans
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- Transcriptional regulation of white adipocyte differentiation
- UCH proteinases
- Interleukin-4 and Interleukin-13 signaling
- RUNX3 regulates CDKN1A transcription
- Regulation of RUNX3 expression and activity
- RUNX3 regulates p14-ARF
- TGFBR3 regulates TGF-beta signaling
|
- Hyaluronidase (ovine)
- Terazosin
- Hyaluronidase (human recombinant)
- Foreskin fibroblast (neonatal)
- Foreskin keratinocyte (neonatal)
- Hyaluronidase
|
- Graft-versus-host disease
- Allograft rejection
- Camurati-Engelmann disease; Progressive diaphyseal dysplasia
|
|
|
TMEFF1 |
transmembrane protein with EGF like and two follistatin like domains 1 |
|
|
|