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AHDC1 |
AT-hook DNA binding motif containing 1 |
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AKT1 |
AKT serine/threonine kinase 1 |
- Activation of BAD and translocation to mitochondria
- PIP3 activates AKT signaling
- PIP3 activates AKT signaling
- Downregulation of ERBB2:ERBB3 signaling
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- MTOR signalling
- AKT phosphorylates targets in the cytosol
- AKT phosphorylates targets in the cytosol
- AKT phosphorylates targets in the nucleus
- Negative regulation of the PI3K/AKT network
- eNOS activation
- AKT-mediated inactivation of FOXO1A
- Integrin signaling
- Deactivation of the beta-catenin transactivating complex
- CD28 dependent PI3K/Akt signaling
- Co-inhibition by CTLA4
- G beta:gamma signalling through PI3Kgamma
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- VEGFR2 mediated vascular permeability
- TP53 Regulates Metabolic Genes
- Constitutive Signaling by AKT1 E17K in Cancer
- Interleukin-4 and Interleukin-13 signaling
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Acetylation
- Regulation of TP53 Activity through Association with Co-factors
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
- RAB GEFs exchange GTP for GDP on RABs
- RUNX2 regulates genes involved in cell migration
- Regulation of PTEN stability and activity
- Extra-nuclear estrogen signaling
- Negative regulation of NOTCH4 signaling
- FLT3 Signaling
- Regulation of localization of FOXO transcription factors
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- KEAP1-NFE2L2 pathway
- SARS-CoV-2 targets host intracellular signalling and regulatory pathways
- Mitochondrial unfolded protein response (UPRmt)
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
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- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- Archexin
- Enzastaurin
- Perifosine
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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- PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
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ANKHD1 |
ankyrin repeat and KH domain containing 1 |
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ANP32A |
acidic nuclear phosphoprotein 32 family member A |
- HuR (ELAVL1) binds and stabilizes mRNA
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APBB1 |
amyloid beta precursor protein binding family B member 1 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
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ARHGAP32 |
Rho GTPase activating protein 32 |
- RHOA GTPase cycle
- RHOB GTPase cycle
- RHOC GTPase cycle
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RAC2 GTPase cycle
- RHOD GTPase cycle
- RHOQ GTPase cycle
- RHOG GTPase cycle
- RHOJ GTPase cycle
- RAC3 GTPase cycle
- RHOF GTPase cycle
- Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
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ARID5A |
AT-rich interaction domain 5A |
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ASNS |
asparagine synthetase (glutamine-hydrolyzing) |
- ATF4 activates genes in response to endoplasmic reticulum stress
- Aspartate and asparagine metabolism
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Response of EIF2AK1 (HRI) to heme deficiency
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- Aspartic acid
- Glutamic acid
- ATP
- Asparagine
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ATF5 |
activating transcription factor 5 |
- Response of EIF2AK1 (HRI) to heme deficiency
- Mitochondrial unfolded protein response (UPRmt)
- Mitochondrial unfolded protein response (UPRmt)
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ATP1A3 |
ATPase Na+/K+ transporting subunit alpha 3 |
- Ion homeostasis
- Ion transport by P-type ATPases
- Potential therapeutics for SARS
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- Ouabain
- Bisacodyl
- Tegoprazan
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- Primary torsion dystonia (PTD)
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ATP6V0D1 |
ATPase H+ transporting V0 subunit d1 |
- ROS and RNS production in phagocytes
- XBP1(S) activates chaperone genes
- Insulin receptor recycling
- Transferrin endocytosis and recycling
- Amino acids regulate mTORC1
- Ion channel transport
- Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
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ATXN1L |
ataxin 1 like |
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ATXN2 |
ataxin 2 |
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- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
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ATXN2L |
ataxin 2 like |
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BAALC |
BAALC binder of MAP3K1 and KLF4 |
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BASP1 |
brain abundant membrane attached signal protein 1 |
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BATF2 |
basic leucine zipper ATF-like transcription factor 2 |
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BEND2 |
BEN domain containing 2 |
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BHLHE40 |
basic helix-loop-helix family member e40 |
- BMAL1:CLOCK,NPAS2 activates circadian expression
- Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
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BICRAL |
BICRA like chromatin remodeling complex associated protein |
- Formation of the non-canonical BAF (ncBAF) complex
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