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TRAT1 |
T cell receptor associated transmembrane adaptor 1 |
- PIP3 activates AKT signaling
- Downstream TCR signaling
- Constitutive Signaling by Aberrant PI3K in Cancer
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
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TRIM35 |
tripartite motif containing 35 |
- Interferon gamma signaling
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TRPV4 |
transient receptor potential cation channel subfamily V member 4 |
- TRP channels
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
- High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
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- Cannabidiol
- Butamben
- Medical Cannabis
- Nabiximols
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- Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
- TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia
- Distal hereditary motor neuropathies (dHMN)
- TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
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TUB |
TUB bipartite transcription factor |
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- (1R,2R,3S,4R,6S)-3,4,6-Trihydroxy-5-{[(S)-hydroxy(3-hydroxy-2-oxopropoxy)phosphoryl]oxy}-1,2-cyclohexanediyl bis[dihydrogen (phosphate)]
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UBAP2 |
ubiquitin associated protein 2 |
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UBE3A |
ubiquitin protein ligase E3A |
- Antigen processing: Ubiquitination & Proteasome degradation
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- Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
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UHRF2 |
ubiquitin like with PHD and ring finger domains 2 |
- SUMOylation of transcription cofactors
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UNC119 |
unc-119 lipid binding chaperone |
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VAV1 |
vav guanine nucleotide exchange factor 1 |
- GPVI-mediated activation cascade
- GPVI-mediated activation cascade
- PIP3 activates AKT signaling
- Signaling by SCF-KIT
- NRAGE signals death through JNK
- Regulation of actin dynamics for phagocytic cup formation
- Constitutive Signaling by Aberrant PI3K in Cancer
- FCERI mediated MAPK activation
- FCERI mediated Ca+2 mobilization
- FCERI mediated Ca+2 mobilization
- CD28 dependent Vav1 pathway
- G alpha (12/13) signalling events
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- Interleukin-3, Interleukin-5 and GM-CSF signaling
- VEGFR2 mediated vascular permeability
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- RHOA GTPase cycle
- RAC1 GTPase cycle
- RAC2 GTPase cycle
- RHOG GTPase cycle
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
- Potential therapeutics for SARS
- Azathioprine ADME
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
- Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
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WAS |
WASP actin nucleation promoting factor |
- Generation of second messenger molecules
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RHOJ GTPase cycle
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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- Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
- Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
- Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
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WASL |
WASP like actin nucleation promoting factor |
- Regulation of actin dynamics for phagocytic cup formation
- Regulation of actin dynamics for phagocytic cup formation
- NOSTRIN mediated eNOS trafficking
- Nephrin family interactions
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- DCC mediated attractive signaling
- RHO GTPases Activate WASPs and WAVEs
- RHO GTPases Activate WASPs and WAVEs
- Clathrin-mediated endocytosis
- CDC42 GTPase cycle
- RAC1 GTPase cycle
- RHOQ GTPase cycle
- RHOJ GTPase cycle
- RHOV GTPase cycle
- FCGR3A-mediated phagocytosis
- FCGR3A-mediated phagocytosis
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YBX1 |
Y-box binding protein 1 |
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- Processing of Capped Intron-Containing Pre-mRNA
- Interferon gamma signaling
- Noncanonical activation of NOTCH3
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ZAP70 |
zeta chain of T cell receptor associated protein kinase 70 |
- Translocation of ZAP-70 to Immunological synapse
- Generation of second messenger molecules
- RHOH GTPase cycle
- Nuclear events stimulated by ALK signaling in cancer
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- Staurosporine
- Fostamatinib
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- Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
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ZSCAN20 |
zinc finger and SCAN domain containing 20 |
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