HRAS - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
RALGDS	ral guanine nucleotide dissociation stimulator	p38MAPK events p38MAPK events RAF/MAP kinase cascade
RAP1B	RAP1B, member of RAS oncogene family	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
RAP1GDS1	Rap1 GTPase-GDP dissociation stimulator 1	RHOT2 GTPase cycle RHOT1 GTPase cycle
RAPGEF1	Rap guanine nucleotide exchange factor 1	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 RAC3 GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
RASA1	RAS p21 protein activator 1	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
RASA2	RAS p21 protein activator 2	Regulation of RAS by GAPs
RASA4	RAS p21 protein activator 4	Regulation of RAS by GAPs
RASGRF1	Ras protein specific guanine nucleotide releasing factor 1	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
RASGRP1	RAS guanyl releasing protein 1	Effects of PIP2 hydrolysis Activation of RAS in B cells Activation of RAS in B cells FCERI mediated NF-kB activation Integrin signaling Rap1 signalling RAF/MAP kinase cascade
RASGRP4	RAS guanyl releasing protein 4	FCERI mediated NF-kB activation RAF/MAP kinase cascade
RASIP1	Ras interacting protein 1
RASSF1	Ras association domain family member 1		Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
RASSF2	Ras association domain family member 2
RASSF5	Ras association domain family member 5
RGL1	ral guanine nucleotide dissociation stimulator like 1	PPARA activates gene expression RAF/MAP kinase cascade
RGL2	ral guanine nucleotide dissociation stimulator like 2	RAF/MAP kinase cascade
RGL4	ral guanine nucleotide dissociation stimulator like 4
RGS12	regulator of G protein signaling 12	G alpha (i) signalling events G alpha (i) signalling events
RHOD	ras homolog family member D	RHO GTPases Activate Formins RHOD GTPase cycle
RIN1	Ras and Rab interactor 1	RAB GEFs exchange GTP for GDP on RABs

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