STK11 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SIK1	salt inducible kinase 1	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes	Dabrafenib Fostamatinib
SIRT1	sirtuin 1	Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation Heme signaling Negative Regulation of CDH1 Gene Transcription MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of MITF-M dependent genes involved in metabolism Transcriptional and post-translational regulation of MITF-M expression and activity Expression of BMAL (ARNTL), CLOCK, and NPAS2	Resveratrol Selisistat Cambinol
SKP2	S-phase kinase associated protein 2	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Regulation of BACH1 activity Antigen processing: Ubiquitination & Proteasome degradation
SMAD1	SMAD family member 1	Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development Cardiogenesis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
SMARCA4	SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4	Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Negative Regulation of CDH1 Gene Transcription Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SNRK	SNF related kinase		Fostamatinib
SOX4	SRY-box transcription factor 4	Deactivation of the beta-catenin transactivating complex
SPDEF	SAM pointed domain containing ETS transcription factor
ST14	ST14 transmembrane serine protease matriptase	Formation of the cornified envelope Formation of the cornified envelope	Urokinase Benzamidine Camostat	Ichthyosis with hypotrichosis
STK11IP	serine/threonine kinase 11 interacting protein	Neutrophil degranulation
STK24	serine/threonine kinase 24	Apoptotic cleavage of cellular proteins Apoptotic execution phase	Fostamatinib
STRADA	STE20 related adaptor alpha	Energy dependent regulation of mTOR by LKB1-AMPK
STRADB	STE20 related adaptor beta	Energy dependent regulation of mTOR by LKB1-AMPK
STX17	syntaxin 17	COPII-mediated vesicle transport
TBC1D23	TBC1 domain family member 23
TDRD7	tudor domain containing 7
TEAD2	TEA domain transcription factor 2	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription
TERT	telomerase reverse transcriptase	Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	Zidovudine Grn163l Tertomotide	Cri du chat syndrome; Cat cry syndrome; Chromosme 5p deletion syndrome
THOP1	thimet oligopeptidase 1	Antigen processing: Ubiquitination & Proteasome degradation
THRSP	thyroid hormone responsive	Carnitine shuttle MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis

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