UBC - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
DNAJA2	DnaJ heat shock protein family (Hsp40) member A2	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
DNAJB2	DnaJ heat shock protein family (Hsp40) member B2
DNAJC3	DnaJ heat shock protein family (Hsp40) member C3	Viral mRNA Translation XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation PKR-mediated signaling
DNASE2B	deoxyribonuclease 2 beta
DNMBP	dynamin binding protein	CDC42 GTPase cycle
DNMT1	DNA methyltransferase 1	PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer	Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
DOCK6	dedicator of cytokinesis 6	CDC42 GTPase cycle RAC1 GTPase cycle Factors involved in megakaryocyte development and platelet production
DPH1	diphthamide biosynthesis 1	Synthesis of diphthamide-EEF2
DPY30	dpy-30 histone methyltransferase complex regulatory subunit	PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of PD-L1(CD274) transcription Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome
DTX2	deltex E3 ubiquitin ligase 2	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
EBI3	Epstein-Barr virus induced 3	Interleukin-35 Signalling Interleukin-27 signaling
ECD	ecdysoneless cell cycle regulator
ECE2	endothelin converting enzyme 2	Peptide ligand-binding receptors
EFS	embryonal Fyn-associated substrate
EGFL7	EGF like domain multiple 7
EIF3A	eukaryotic translation initiation factor 3 subunit A	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF3H	eukaryotic translation initiation factor 3 subunit H	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF3I	eukaryotic translation initiation factor 3 subunit I	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4E2	eukaryotic translation initiation factor 4E family member 2	ISG15 antiviral mechanism
ELL	elongation factor for RNA polymerase II	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation

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