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SMURF2 |
SMAD specific E3 ubiquitin protein ligase 2 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Hedgehog 'on' state
- Hedgehog 'on' state
- Ub-specific processing proteases
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SNRNP70 |
small nuclear ribonucleoprotein U1 subunit 70 |
- mRNA Splicing - Major Pathway
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SNW1 |
SNW domain containing 1 |
- Pre-NOTCH Transcription and Translation
- Pre-NOTCH Transcription and Translation
- Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
- NOTCH1 Intracellular Domain Regulates Transcription
- NOTCH1 Intracellular Domain Regulates Transcription
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Notch-HLH transcription pathway
- mRNA Splicing - Major Pathway
- RUNX3 regulates NOTCH signaling
- RUNX3 regulates NOTCH signaling
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH3 Intracellular Domain Regulates Transcription
- NOTCH4 Intracellular Domain Regulates Transcription
- Formation of paraxial mesoderm
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SP1 |
Sp1 transcription factor |
- PPARA activates gene expression
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Activation of gene expression by SREBF (SREBP)
- Oncogene Induced Senescence
- RNA polymerase II transcribes snRNA genes
- RNA polymerase II transcribes snRNA genes
- Estrogen-dependent gene expression
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Regulation of CDH11 gene transcription
- Regulation of CDH11 gene transcription
- Positive Regulation of CDH1 Gene Transcription
- NFE2L2 regulating tumorigenic genes
- TGFBR3 expression
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SPTBN1 |
spectrin beta, non-erythrocytic 1 |
- Nephrin family interactions
- NCAM signaling for neurite out-growth
- NCAM signaling for neurite out-growth
- Interaction between L1 and Ankyrins
- Interaction between L1 and Ankyrins
- RAF/MAP kinase cascade
- COPI-mediated anterograde transport
- RHOU GTPase cycle
- RHOV GTPase cycle
- Sensory processing of sound by inner hair cells of the cochlea
- Sensory processing of sound by outer hair cells of the cochlea
- Signaling by FLT3 fusion proteins
- Signaling by FLT3 fusion proteins
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- Calcium
- 1D-myo-inositol 1,4,5-trisphosphate
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SQSTM1 |
sequestosome 1 |
- NRIF signals cell death from the nucleus
- p75NTR recruits signalling complexes
- NF-kB is activated and signals survival
- PINK1-PRKN Mediated Mitophagy
- Neddylation
- Interleukin-1 signaling
- Pexophagy
- Signaling by ALK fusions and activated point mutants
- KEAP1-NFE2L2 pathway
- Nuclear events mediated by NFE2L2
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- Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
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SREBF2 |
sterol regulatory element binding transcription factor 2 |
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Cholesterol biosynthesis
- PPARA activates gene expression
- Activation of gene expression by SREBF (SREBP)
- Activation of gene expression by SREBF (SREBP)
- Transcriptional regulation of white adipocyte differentiation
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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SRY |
sex determining region Y |
- Deactivation of the beta-catenin transactivating complex
- Transcriptional regulation of testis differentiation
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- 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
- 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
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SS18L1 |
SS18L1 subunit of BAF chromatin remodeling complex |
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of MITF-M-dependent genes involved in pigmentation
- Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
- Formation of the canonical BAF (cBAF) complex
- Formation of the non-canonical BAF (ncBAF) complex
- Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
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ST6GALNAC2 |
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
- Sialic acid metabolism
- Maturation of protein 3a
- Maturation of spike protein
- Maturation of protein 3a
- Termination of O-glycan biosynthesis
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STRAP |
serine/threonine kinase receptor associated protein |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Positive Regulation of CDH1 Gene Transcription
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STUB1 |
STIP1 homology and U-box containing protein 1 |
- Downregulation of TGF-beta receptor signaling
- RIPK1-mediated regulated necrosis
- Regulation of TNFR1 signaling
- Regulation of necroptotic cell death
- Downregulation of ERBB2 signaling
- Regulation of RUNX2 expression and activity
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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SVEP1 |
sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 |
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TANK |
TRAF family member associated NFKB activator |
- TICAM1-dependent activation of IRF3/IRF7
- TRAF6 mediated IRF7 activation
- Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
- Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
- Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
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TDP2 |
tyrosyl-DNA phosphodiesterase 2 |
- Nonhomologous End-Joining (NHEJ)
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TEKT4 |
tektin 4 |
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TF |
transferrin |
- Platelet degranulation
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- Post-translational protein phosphorylation
- Iron uptake and transport
- Transferrin endocytosis and recycling
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- Cisplatin
- Isoflurophate
- Aluminium
- Iron
- Zinc
- Manganese
- Copper
- Dichlorvos
- Zinc acetate
- Ferrous gluconate
- Ferrous succinate
- Ferrous ascorbate
- Ferrous fumarate
- Ferrous glycine sulfate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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TFE3 |
transcription factor binding to IGHM enhancer 3 |
- Transcriptional and post-translational regulation of MITF-M expression and activity
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- Alveolar soft part sarcoma
- Renal cell carcinoma
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TGFBR1 |
transforming growth factor beta receptor 1 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- Ub-specific processing proteases
- TGFBR3 regulates TGF-beta signaling
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- 4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
- Naphthyridine Inhibitor
- 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
- N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
- 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
- N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
- Fostamatinib
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- Loeys-Dietz syndrome (LDS)
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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TGFBR2 |
transforming growth factor beta receptor 2 |
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- TGFBR2 MSI Frameshift Mutants in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- TGFBR1 LBD Mutants in Cancer
- UCH proteinases
- TGFBR3 regulates TGF-beta signaling
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- Foreskin fibroblast (neonatal)
- Foreskin keratinocyte (neonatal)
- Fostamatinib
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- Loeys-Dietz syndrome (LDS)
- Colorectal cancer
- Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
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