Search Results for: ATXN1

294 interactions involving ATXN1 - ataxin 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
SF1 splicing factor 1
  • mRNA Splicing - Major Pathway
  • Artenimol
SGMS1 sphingomyelin synthase 1
  • Sphingolipid de novo biosynthesis
SIX5 SIX homeobox 5
  • Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
SLC25A51 solute carrier family 25 member 51
  • Nicotinate metabolism
SLC4A2 solute carrier family 4 member 2
  • Bicarbonate transporters
SLC51A solute carrier family 51 member A
  • Recycling of bile acids and salts
SLC6A13 solute carrier family 6 member 13
  • SLC-mediated transport of neurotransmitters
  • Reuptake of GABA
  • Guvacine
SMARCC2 SWI/SNF related BAF chromatin remodeling complex subunit C2
  • RMTs methylate histone arginines
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of MITF-M-dependent genes involved in pigmentation
  • Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
  • Formation of the polybromo-BAF (pBAF) complex
  • Formation of the embryonic stem cell BAF (esBAF) complex
  • Formation of the non-canonical BAF (ncBAF) complex
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
  • Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
SORCS3 sortilin related VPS10 domain containing receptor 3
SOX3 SRY-box transcription factor 3
  • Deactivation of the beta-catenin transactivating complex
  • Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
  • Septo-optic dysplasia
  • 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
  • Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
SPEN spen family transcriptional repressor
  • RHOBTB1 GTPase cycle
SREBF1 sterol regulatory element binding transcription factor 1
  • Cholesterol biosynthesis
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
  • Doconexent
  • Omega-3-acid ethyl esters
  • Omega-3 fatty acids
  • Fish oil
SREBF2 sterol regulatory element binding transcription factor 2
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Cholesterol biosynthesis
  • PPARA activates gene expression
  • Activation of gene expression by SREBF (SREBP)
  • Activation of gene expression by SREBF (SREBP)
  • Transcriptional regulation of white adipocyte differentiation
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
  • Sialic acid metabolism
  • Lewis blood group biosynthesis
  • Glycosphingolipid biosynthesis
STAC2 SH3 and cysteine rich domain 2
STAM2 signal transducing adaptor molecule 2
  • EGFR downregulation
  • Ub-specific processing proteases
  • Negative regulation of MET activity
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • RHOU GTPase cycle
  • Endosomal Sorting Complex Required For Transport (ESCRT)
SUGP2 SURP and G-patch domain containing 2
SUMO1 small ubiquitin like modifier 1
  • SUMO is conjugated to E1 (UBA2:SAE1)
  • SUMO is transferred from E1 to E2 (UBE2I, UBC9)
  • SUMO is proteolytically processed
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of transcription factors
  • SUMOylation of transcription factors
  • SUMOylation of ubiquitinylation proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of transcription cofactors
  • SUMOylation of SUMOylation proteins
  • SUMOylation of intracellular receptors
  • SUMOylation of intracellular receptors
  • SUMOylation of chromatin organization proteins
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of immune response proteins
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Formation of Incision Complex in GG-NER
  • Regulation of IFNG signaling
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Postmitotic nuclear pore complex (NPC) reformation
  • Maturation of nucleoprotein
  • Maturation of nucleoprotein
  • SUMOylation of nuclear envelope proteins
  • PKR-mediated signaling
  • Transcriptional and post-translational regulation of MITF-M expression and activity
SUPT20H SPT20 homolog, SAGA complex component
  • HATs acetylate histones
SV2A synaptic vesicle glycoprotein 2A
  • Toxicity of botulinum toxin type D (botD)
  • Toxicity of botulinum toxin type A (botA)
  • Toxicity of botulinum toxin type F (botF)
  • Toxicity of botulinum toxin type E (botE)
  • Levetiracetam
  • Brivaracetam
  • Seletracetam

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