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RRAS2 |
RAS related 2 |
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RUNX2 |
RUNX family transcription factor 2 |
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RUNX3 |
RUNX family transcription factor 3 |
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates NOTCH signaling
- Regulation of RUNX3 expression and activity
- RUNX3 Regulates Immune Response and Cell Migration
- RUNX3 Regulates Immune Response and Cell Migration
- RUNX3 regulates WNT signaling
- RUNX3 regulates YAP1-mediated transcription
- RUNX3 regulates RUNX1-mediated transcription
- RUNX3 regulates p14-ARF
- RUNX3 regulates BCL2L11 (BIM) transcription
- Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
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S100A4 |
S100 calcium binding protein A4 |
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SAP130 |
Sin3A associated protein 130 |
- HATs acetylate histones
- NoRC negatively regulates rRNA expression
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SBK3 |
SH3 domain binding kinase family member 3 |
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SERTAD1 |
SERTA domain containing 1 |
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SETD2 |
SET domain containing 2, histone lysine methyltransferase |
- PKMTs methylate histone lysines
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SF3A1 |
splicing factor 3a subunit 1 |
- mRNA Splicing - Major Pathway
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SF3B2 |
splicing factor 3b subunit 2 |
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
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SIN3A |
SIN3 transcription regulator family member A |
- SUMOylation of transcription cofactors
- Regulation of lipid metabolism by PPARalpha
- NoRC negatively regulates rRNA expression
- RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
- Loss of MECP2 binding ability to 5mC-DNA
- Regulation of MECP2 expression and activity
- MECP2 regulates neuronal receptors and channels
- MECP2 regulates transcription of neuronal ligands
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- STAT3 nuclear events downstream of ALK signaling
- Cytoprotection by HMOX1
- Regulation of MITF-M-dependent genes involved in apoptosis
- Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- Factors involved in megakaryocyte development and platelet production
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SKI |
SKI proto-oncogene |
- Signaling by BMP
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
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SKIL |
SKI like proto-oncogene |
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
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SKOR2 |
SKI family transcriptional corepressor 2 |
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SMAD1 |
SMAD family member 1 |
- Signaling by BMP
- Ub-specific processing proteases
- RUNX2 regulates bone development
- Cardiogenesis
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
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SMAD2 |
SMAD family member 2 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGFBR1 KD Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Germ layer formation at gastrulation
- Formation of axial mesoderm
- Formation of definitive endoderm
- Formation of definitive endoderm
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SMAD4 |
SMAD family member 4 |
- Signaling by NODAL
- Signaling by NODAL
- Signaling by Activin
- Signaling by Activin
- Signaling by BMP
- TGF-beta receptor signaling activates SMADs
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD4 MH2 Domain Mutants in Cancer
- SMAD2/3 MH2 Domain Mutants in Cancer
- Transcriptional regulation of pluripotent stem cells
- Ub-specific processing proteases
- RUNX2 regulates bone development
- RUNX3 regulates CDKN1A transcription
- RUNX3 regulates BCL2L11 (BIM) transcription
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- FOXO-mediated transcription of cell cycle genes
- FOXO-mediated transcription of cell cycle genes
- Cardiogenesis
- SARS-CoV-1 targets host intracellular signalling and regulatory pathways
- Germ layer formation at gastrulation
- Formation of definitive endoderm
- Formation of definitive endoderm
- TGFBR3 expression
- Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
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- Colorectal cancer
- Juvenile polyposis syndrome
- Hereditary hemorrhagic telangiectasia (HHT)
- Pancreatic cancer
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SMAD7 |
SMAD family member 7 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- Downregulation of TGF-beta receptor signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- UCH proteinases
- Ub-specific processing proteases
- Interferon gamma signaling
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SMAD9 |
SMAD family member 9 |
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SMURF1 |
SMAD specific E3 ubiquitin protein ligase 1 |
- Signaling by BMP
- Downregulation of TGF-beta receptor signaling
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- Asymmetric localization of PCP proteins
- Hedgehog 'on' state
- Hedgehog 'on' state
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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