OGT - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
GATB	glutamyl-tRNA amidotransferase subunit B
GBA1	glucosylceramidase beta 1	Association of TriC/CCT with target proteins during biosynthesis Glycosphingolipid catabolism	scyllo-inositol N-acetyl-alpha-D-glucosamine Velaglucerase alfa (2R,3R,4R,5S)-2-(HYDROXYMETHYL)-1-NONYLPIPERIDINE-3,4,5-TRIOL	Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Gaucher disease
GDI1	GDP dissociation inhibitor 1	RAB GEFs exchange GTP for GDP on RABs		Non-syndromic X-linked mental retardation
GDI2	GDP dissociation inhibitor 2	Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs
GLA	galactosidase alpha	Neutrophil degranulation Glycosphingolipid catabolism	Migalastat	Fabry disease
GLMN	glomulin, FKBP associated protein	Antigen processing: Ubiquitination & Proteasome degradation		Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GLS	glutaminase	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism	Glutamic acid
GLUD1	glutamate dehydrogenase 1	Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism Mitochondrial protein degradation	Glutamic acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
GNL3	G protein nucleolar 3	Major pathway of rRNA processing in the nucleolus and cytosol
GORASP2	golgi reassembly stacking protein 2	Golgi Cisternae Pericentriolar Stack Reorganization
GPATCH4	G-patch domain containing 4 (gene/pseudogene)
GPKOW	G-patch domain and KOW motifs	mRNA Splicing - Major Pathway
GPS1	G protein pathway suppressor 1	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
GPT2	glutamic--pyruvic transaminase 2		Pyridoxal phosphate Glutamic acid Alanine Phenelzine
GRSF1	G-rich RNA sequence binding factor 1	Viral mRNA Translation Mitochondrial RNA degradation
GRWD1	glutamate rich WD repeat containing 1
GSK3A	glycogen synthase kinase 3 alpha	AKT phosphorylates targets in the cytosol XBP1(S) activates chaperone genes Constitutive Signaling by AKT1 E17K in Cancer Suppression of apoptosis Maturation of nucleoprotein Maturation of nucleoprotein	Fostamatinib
GSK3B	glycogen synthase kinase 3 beta	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Maturation of nucleoprotein Maturation of nucleoprotein GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Transcriptional and post-translational regulation of MITF-M expression and activity GSK3B-mediated proteasomal degradation of PD-L1(CD274)	Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate
GSS	glutathione synthetase	Glutathione synthesis and recycling Defective GSS causes GSS deficiency	Glutathione Glycine Cysteine gamma-Glutamylcysteine Phosphoaminophosphonic Acid-Adenylate Ester Acetylcysteine Copper	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GSTM3	glutathione S-transferase mu 3	Glutathione conjugation	Glutathione Glutathione disulfide Deoxycholic acid

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