ESR1 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	NR0B1	nuclear receptor subfamily 0 group B member 1		Dexamethasone Dexamethasone acetate	Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
Novel	NR0B2	nuclear receptor subfamily 0 group B member 2	Nuclear Receptor transcription pathway
Novel	NR1H4	nuclear receptor subfamily 1 group H member 4	Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols	alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh Nidufexor Tropifexor
Novel	NR2C1	nuclear receptor subfamily 2 group C member 1	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Novel	NR2C2	nuclear receptor subfamily 2 group C member 2	Nuclear Receptor transcription pathway
Novel	NR2F1	nuclear receptor subfamily 2 group F member 1	Nuclear Receptor transcription pathway	beta-Naphthoflavone
Novel	NR2F6	nuclear receptor subfamily 2 group F member 6	Nuclear Receptor transcription pathway
Novel	NRIP1	nuclear receptor interacting protein 1	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Novel	NSD1	nuclear receptor binding SET domain protein 1	PKMTs methylate histone lysines		Sotos syndrome and Weaver syndrome Beckwith-Wiedemann syndrome
Novel	NSD2	nuclear receptor binding SET domain protein 2	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint		Multiple myeloma
Novel	NSD3	nuclear receptor binding SET domain protein 3	PKMTs methylate histone lysines
Novel	NSF	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	1-Ethyl-Pyrrolidine-2,5-Dione
Novel	NUDT21	nudix hydrolase 21	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Novel	OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1	Ub-specific processing proteases Ovarian tumor domain proteases
Novel	P4HB	prolyl 4-hydroxylase subunit beta	Collagen biosynthesis and modifying enzymes Insulin processing Detoxification of Reactive Oxygen Species Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Hedgehog ligand biogenesis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly LDL remodeling Interleukin-12 signaling Interleukin-23 signaling	Zinc Ribostamycin Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Novel	PA2G4	proliferation-associated 2G4	Neutrophil degranulation
Novel	PAGR1	PAXIP1 associated glutamate rich protein 1	Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Novel	PAK1	p21 (RAC1) activated kinase 1	Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation FCERI mediated MAPK activation FCERI mediated MAPK activation CD28 dependent Vav1 pathway EPHB-mediated forward signaling Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 Signal transduction by L1 Smooth Muscle Contraction VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PKNs RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Fostamatinib
Novel	PAK6	p21 (RAC1) activated kinase 6	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle	Fostamatinib
Novel	PBXIP1	PBX homeobox interacting protein 1

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