APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
BKGD	beta-keto-L-gulonate decarboxylase
BLMH	bleomycin hydrolase	Antigen processing: Ubiquitination & Proteasome degradation
BLOC1S1	biogenesis of lysosomal organelles complex 1 subunit 1	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
BLOC1S2	biogenesis of lysosomal organelles complex 1 subunit 2
BLOC1S5	biogenesis of lysosomal organelles complex 1 subunit 5
BLOC1S6	biogenesis of lysosomal organelles complex 1 subunit 6	Golgi Associated Vesicle Biogenesis
BMPR1B	bone morphogenetic protein receptor type 1B	Signaling by BMP	Fostamatinib	Acromesomelic dysplasia with genital anomalies Brachydactyly, including: type A; type B; type D; type E
BMX	BMX non-receptor tyrosine kinase	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	Fostamatinib Zanubrutinib
BNIP1	BCL2 interacting protein 1	COPI-dependent Golgi-to-ER retrograde traffic
BOD1	biorientation of chromosomes in cell division 1	Formation of WDR5-containing histone-modifying complexes
BOLA1	bolA family member 1
BRD3	bromodomain containing 3
BRF1	BRF1 general transcription factor IIIB subunit	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
BRME1	break repair meiotic recombinase recruitment factor 1
BRMS1	BRMS1 transcriptional repressor and anoikis regulator	HDACs deacetylate histones Potential therapeutics for SARS
BRWD1	bromodomain and WD repeat domain containing 1	Interleukin-7 signaling Interleukin-7 signaling Chromatin modifying enzymes
BSND	barttin CLCNK type accessory subunit beta	Stimuli-sensing channels		Bartter syndrome
BTF3	basic transcription factor 3
BTK	Bruton tyrosine kinase	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Spebrutinib Fostamatinib Fenebrutinib Zanubrutinib Evobrutinib Tirabrutinib Abivertinib Branebrutinib Vecabrutinib	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
BUD31	BUD31 spliceosome associated protein	mRNA Splicing - Major Pathway

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