TRAF1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
TBC1D16	TBC1 domain family member 16	TBC/RABGAPs
TBC1D8	TBC1 domain family member 8
TBX18	T-box transcription factor 18
TCEA2	transcription elongation factor A2
TCF7L2	transcription factor 7 like 2	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Formation of definitive endoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription		Type II diabetes mellitus
TCL1A	TCL1 family AKT coactivator A
TEAD4	TEA domain transcription factor 4	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription
TFAP2D	transcription factor AP-2 delta	Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
TFAP4	transcription factor AP-4
TFPT	TCF3 fusion partner	UCH proteinases DNA Damage Recognition in GG-NER
THAP7	THAP domain containing 7
TICAM1	TIR domain containing adaptor molecule 1	Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
TIFA	TRAF interacting protein with forkhead associated domain	TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway
TLE5	TLE family member 5, transcriptional modulator	Repression of WNT target genes
TNFAIP3	TNF alpha induced protein 3	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
TNFRSF11A	TNF receptor superfamily member 11a	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	ENMD-1198	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
TNFRSF12A	TNF receptor superfamily member 12A	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFRSF14	TNF receptor superfamily member 14	TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
TNFRSF17	TNF receptor superfamily member 17	TNFs bind their physiological receptors	Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel
TNFRSF18	TNF receptor superfamily member 18	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

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