Search Results for: CDKN2A

346 interactions involving CDKN2A - cyclin dependent kinase inhibitor 2A found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ALDOB aldolase, fructose-bisphosphate B
  • Hereditary fructose intolerance
  • Glycolysis
  • Gluconeogenesis
  • Fructose catabolism
  • 1,6-Fructose Diphosphate (Linear Form)
  • sn-glycerol 3-phosphate
  • Dihydroxyacetone phosphate
  • Hereditary fructose intolerance; Fructosemia
ANAPC15 anaphase promoting complex subunit 15
  • Inactivation of APC/C via direct inhibition of the APC/C complex
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
  • Regulation of APC/C activators between G1/S and early anaphase
  • APC/C:Cdc20 mediated degradation of mitotic proteins
  • Phosphorylation of the APC/C
  • APC-Cdc20 mediated degradation of Nek2A
  • Separation of Sister Chromatids
  • Senescence-Associated Secretory Phenotype (SASP)
  • Assembly of the pre-replicative complex
  • CDK-mediated phosphorylation and removal of Cdc6
  • Transcriptional Regulation by VENTX
  • Aberrant regulation of mitotic exit in cancer due to RB1 defects
ANGPTL4 angiopoietin like 4
  • PPARA activates gene expression
  • Transcriptional regulation of white adipocyte differentiation
  • Assembly of active LPL and LIPC lipase complexes
  • Regulation of CDH11 function
  • MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
ANKRA2 ankyrin repeat family A member 2
ANKRD12 ankyrin repeat domain 12
AOPEP aminopeptidase O (putative)
ARFIP2 ARF interacting protein 2
  • Retrograde transport at the Trans-Golgi-Network
ARNT aryl hydrocarbon receptor nuclear translocator
  • Regulation of gene expression by Hypoxia-inducible Factor
  • PPARA activates gene expression
  • Phase I - Functionalization of compounds
  • Endogenous sterols
  • Xenobiotics
  • Aryl hydrocarbon receptor signalling
  • NPAS4 regulates expression of target genes
  • NPAS4 regulates expression of target genes
ASPRV1 aspartic peptidase retroviral like 1
AZIN1 antizyme inhibitor 1
  • Regulation of ornithine decarboxylase (ODC)
BAAT bile acid-CoA:amino acid N-acyltransferase
  • Recycling of bile acids and salts
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
  • Peroxisomal protein import
  • Peroxisomal protein import
  • Glycine
  • Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
BCL2L1 BCL2 like 1
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • Interleukin-4 and Interleukin-13 signaling
  • The NLRP1 inflammasome
  • RAS processing
  • SARS-CoV-1-mediated effects on programmed cell death
  • STAT5 activation downstream of FLT3 ITD mutants
  • NFE2L2 regulating tumorigenic genes
  • 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID
  • Gossypol
BECN1 beclin 1
  • ISG15 antiviral mechanism
  • Macroautophagy
  • Ub-specific processing proteases
  • Translation of Replicase and Assembly of the Replication Transcription Complex
  • Translation of Replicase and Assembly of the Replication Transcription Complex
  • SARS-CoV-2 activates/modulates innate and adaptive immune responses
  • Antigen Presentation: Folding, assembly and peptide loading of class I MHC
  • RSV-host interactions
  • Estradiol
  • Estradiol acetate
  • Estradiol benzoate
  • Estradiol cypionate
  • Estradiol dienanthate
  • Estradiol valerate
CA9 carbonic anhydrase 9
  • Regulation of gene expression by Hypoxia-inducible Factor
  • Reversible hydration of carbon dioxide
  • Benzthiazide
  • Benzthiazide
  • Cyclothiazide
  • Hydroflumethiazide
  • Zonisamide
  • Girentuximab
  • Ellagic acid
  • Sodium carbonate
  • DTP-348
CARF calcium responsive transcription factor
CASC3 CASC3 exon junction complex subunit
  • Transport of Mature mRNA derived from an Intron-Containing Transcript
  • mRNA Splicing - Major Pathway
  • mRNA 3'-end processing
  • RNA Polymerase II Transcription Termination
  • Regulation of expression of SLITs and ROBOs
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
CCDC180 coiled-coil domain containing 180
CCDC183 coiled-coil domain containing 183
CCND2 cyclin D2
  • Cyclin D associated events in G1
  • Regulation of RUNX1 Expression and Activity
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • Drug-mediated inhibition of CDK4/CDK6 activity
  • Testicular cancer
CCNDBP1 cyclin D1 binding protein 1

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