APP - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
BCAP31	B cell receptor associated protein 31	Apoptotic cleavage of cellular proteins Apoptotic execution phase RHOA GTPase cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC RSV-host interactions
BCAR3	BCAR3 adaptor protein, NSP family member
BCAT2	branched chain amino acid transaminase 2	Branched-chain amino acid catabolism	Pyridoxal phosphate Glutamic acid Leucine Isoleucine Pyridoxamine-5'-Phosphate N-[O-Phosphono-Pyridoxyl]-Isoleucine alpha-Ketoisovalerate
BCKDK	branched chain keto acid dehydrogenase kinase	Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency	Adenosine 5'-[gamma-thio]triphosphate
BCL11A	BCL11 transcription factor A	ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
BCL2A1	BCL2 related protein A1	Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in apoptosis
BCL2L11	BCL2 like 11	Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF1 fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription FLT3 Signaling FOXO-mediated transcription of cell death genes
BCL2L13	BCL2 like 13
BCL7C	BAF chromatin remodeling complex subunit BCL7C	Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
BDH1	3-hydroxybutyrate dehydrogenase 1	Utilization of Ketone Bodies Synthesis of Ketone Bodies Mitochondrial protein degradation	NADH
BDNF	brain derived neurotrophic factor	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MECP2 regulates transcription of neuronal ligands BDNF activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5 NPAS4 regulates expression of target genes	CX-717 Copper Chondroitin sulfate Esketamine	Congenital central hypoventilation syndrome (CCHS)
BEGAIN	brain enriched guanylate kinase associated	Neurexins and neuroligins
BEND2	BEN domain containing 2
BEND5	BEN domain containing 5
BET1L	Bet1 golgi vesicular membrane trafficking protein like	COPI-mediated anterograde transport Intra-Golgi traffic
BGN	biglycan	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
BHMT2	betaine--homocysteine S-methyltransferase 2	Sulfur amino acid metabolism	Methionine
BIK	BCL2 interacting killer
BIN1	bridging integrator 1	Clathrin-mediated endocytosis		Centronuclear myopathy
BIN3-IT1	BIN3 intronic transcript 1

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