PRKCA - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	FOXJ1	forkhead box J1
Novel	PRKACA	protein kinase cAMP-activated catalytic subunit alpha	PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Interleukin-3, Interleukin-5 and GM-CSF signaling Ion homeostasis Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Anchoring of the basal body to the plasma membrane CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling AURKA Activation by TPX2 HDL assembly ROBO receptors bind AKAP5 Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity GPER1 signaling GPER1 signaling Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production Mitochondrial protein degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Pentanal Balanol Analog 2 3-[(3-sec-butyl-4-hydroxybenzoyl)amino]azepan-4-yl 4-(2-hydroxy-5-methoxybenzoyl)benzoate Phosphonothreonine Balanol Analog 1 3,5-Diiodotyrosine Balanol Dexfosfoserine S,S-(2-Hydroxyethyl)Thiocysteine Hydroxyfasudil (2S)-1-(3H-Indol-3-yl)-3-{[5-(6-isoquinolinyl)-3-pyridinyl]oxy}-2-propanamine (2S)-1-{[5-(1H-Indazol-5-yl)-3-pyridinyl]oxy}-3-(7aH-indol-3-yl)-2-propanamine (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE (2S)-1-(6H-INDOL-3-YL)-3-{[5-(7H-PYRAZOLO[3,4-C]PYRIDIN-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE N-METHYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE (S)-1-PHENYL-1-[4-(9H-PURIN-6-YL)PHENYL]METHANAMINE 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE (2R)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine (2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE H-89 5-(2-methylpiperazine-1-sulfonyl)isoquinoline N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE 3-pyridin-4-yl-1H-indazole 5-benzyl-1,3-thiazol-2-amine 1-[4-(4-chlorophenyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 1-[4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl]methanamine 4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-aminium Fasudil Myristic acid A-674563 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.] PYRAZOLE Y-27632 Ellagic acid Fostamatinib
	ACTA1	actin alpha 1, skeletal muscle	Striated Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B	Cap myopathy Congenital fiber type disproportion (CFTD) Nemaline myopathy
	ADAP1	ArfGAP with dual PH domains 1	Nuclear signaling by ERBB4
	ADCY5	adenylate cyclase 5	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Colforsin Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE Aurothioglucose
	ADD1	adducin 1	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
	ADD3	adducin 3	Miscellaneous transport and binding events RHOD GTPase cycle RHOF GTPase cycle
	ADRA1B	adrenoceptor alpha 1B	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events	Amphetamine Midodrine Ranolazine Ziprasidone Cabergoline Ropinirole Dapiprazole Dihydroergotamine Amitriptyline Olanzapine Alfuzosin Alfuzosin Clozapine Norepinephrine Mirtazapine Phenylephrine Loxapine Prochlorperazine Prazosin Prazosin Imipramine Chlorpromazine Chlorpromazine Buspirone Nortriptyline Amoxapine Clonidine Doxazosin Labetalol Nicardipine Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Tizanidine Tamsulosin Paroxetine Methoxamine Trimipramine Risperidone Modafinil Fenoldopam Dobutamine Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Ergoloid mesylate Promethazine Carvedilol Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Mephentermine Methotrimeprazine Dextroamphetamine Dextroamphetamine Phendimetrazine Periciazine Acepromazine Thioproperazine Dronedarone R450 Epicept NP-1 Sertindole Mianserin Pizotifen Silodosin Ocaperidone Droxidopa Xylometazoline Tetryzoline Perospirone Brexpiprazole Dosulepin Viloxazine Etoperidone Lorpiprazole Cirazoline Synephrine Arotinolol Moxisylyte Aranidipine Pipamperone Racepinephrine Dihydroergocornine DL-Methylephedrine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
	AFAP1	actin filament associated protein 1
	AKAP12	A-kinase anchoring protein 12	RHOD GTPase cycle RHOF GTPase cycle
	AKAP5	A-kinase anchoring protein 5	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Trafficking of AMPA receptors ROBO receptors bind AKAP5 ROBO receptors bind AKAP5
	ANXA2	annexin A2	Smooth Muscle Contraction Neutrophil degranulation Dissolution of Fibrin Clot Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Pancreatic Ductal Cells	Tenecteplase Fluocinolone acetonide Lanoteplase Artenimol
	ANXA7	annexin A7
	APLP2	amyloid beta precursor like protein 2	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
	ARHGEF1	Rho guanine nucleotide exchange factor 1	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
	ATP1A1	ATPase Na+/K+ transporting subunit alpha 1	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS	Digoxin Acetyldigitoxin Hydroflumethiazide Etacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Ciclopirox Bepridil Potassium cation Aluminium Magnesium cation Digitoxin Almitrine Istaroxime Bisacodyl Magnesium acetate Potassium acetate Potassium sulfate Potassium Magnesium levulinate Magnesium lactate Aluminium phosphate Aluminum acetate Tegoprazan
	ATP2B1	ATPase plasma membrane Ca2+ transporting 1	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases Sensory processing of sound by inner hair cells of the cochlea	Ritodrine Halothane Desflurane Sevoflurane
	ATP2B2	ATPase plasma membrane Ca2+ transporting 2	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Ritodrine Halothane Desflurane Sevoflurane
	AVPR1A	arginine vasopressin receptor 1A	Vasopressin-like receptors G alpha (q) signalling events Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)	Desmopressin Vasopressin Felypressin Conivaptan Terlipressin PH-284 Tolvaptan Atosiban Relcovaptan Lypressin Pecavaptan
	BCL2	BCL2 apoptosis regulator	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Regulation of MITF-M-dependent genes involved in apoptosis	Ibuprofen Paclitaxel Docetaxel Rasagiline AN-9 Paclitaxel docosahexaenoic acid Apoptone Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax Terpinen-4-ol Oleandrin	Cervical cancer Kaposi's sarcoma Chronic lymphocytic leukemia (CLL) Gastric cancer Nasopharyngeal cancer Choriocarcinoma Small cell lung cancer

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