PPFIA2 and ERC2

Number of citations of the paper that reports this interaction (PubMedID 12923177)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PPFIA2	ERC2
Description		PPFI scaffold protein A2	ELKS/RAB6-interacting/CAST family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Synaptic Vesicle Cell Surface Postsynaptic Density Axon Presynaptic Membrane Cell Projection Dendritic Spine Synapse Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse Postsynaptic Specialization	Cytoplasm Cytoskeleton Growth Cone Presynaptic Membrane Cell Projection Synapse Presynaptic Active Zone Presynapse Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Structural Constituent Of Postsynaptic Density Structural Constituent Of Presynapse	Protein Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Cell-matrix Adhesion Synapse Organization Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Presynapse Organization Dense Core Granule Cytoskeletal Transport Maintenance Of Postsynaptic Density Structure Regulation Of Synaptic Vesicle Exocytosis	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Age-related cataracts (age at onset) ( 25352737) Alcohol dependence ( 26365420) Delirium ( 29631748) Femur bone mineral density x serum urate levels interaction ( 34046847) Lean body mass ( 28552196) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Schizophrenia ( 22885689)	Acute lymphoblastic leukemia (childhood) ( 22076464) Adult body size ( 32376654) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 26955885) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lateral thalamic nuclei volume ( 34006833) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Sense of smell ( 26632684) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990) Trochanter size ( 31053729)
Interacting Genes		15 interacting genes: CAST CDC5L ERC2 GIT1 ITSN1 MTDH PPFIA1 PPFIA3 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SMARCA2 TSC1	9 interacting genes: BSN MYB NRIP1 PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		8499	26059
HPRD ID		04392	10810
Ensembl ID		ENSG00000139220	ENSG00000187672
Uniprot IDs		B7Z7Y5 G3V200 H0YHK3 O75334	H7C4G9 O15083
PDB IDs		3TAC 3TAD 6IUH 7D2E 7D2G 7D2H
Enriched GO Terms of Interacting Partners?		Synapse Organization Presynaptic Active Zone Cell Junction Organization Synaptic Membrane Adhesion Presynaptic Membrane Glutamatergic Synapse Regulation Of Dendritic Spine Development Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Cortical Microtubule Organization Presynaptic Active Zone Organization Regulation Of Organelle Organization Presynaptic Active Zone Cytoplasmic Component Schaffer Collateral - CA1 Synapse Protein Tyrosine Phosphatase Activity Regulation Of Postsynaptic Density Assembly Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Cellular Component Organization Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Peptidyl-tyrosine Dephosphorylation Neuron Projection Regulation Of Postsynapse Organization Phosphoprotein Phosphatase Activity Regulation Of Axon Regeneration Growth Cone Regulation Of Neuron Projection Regeneration Maintenance Of Synapse Structure Regulation Of Response To Wounding Neuromuscular Junction Development Cell Cortex Positive Regulation Of Dendritic Spine Development Lamellipodium Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Modulation Of Chemical Synaptic Transmission Chondroitin Sulfate Proteoglycan Binding Memory T Cell Differentiation Cortical Cytoskeleton Organization Epididymosome Negative Regulation Of ARF Protein Signal Transduction Cell Junction Maintenance Synapse Presynapse Nervous System Development Postsynaptic Density Cytoplasmic Microtubule Organization Regulation Of Cell Junction Assembly Clathrin-dependent Synaptic Vesicle Endocytosis Cellular Component Maintenance	Presynaptic Active Zone Synapse Organization Cell Junction Organization Maintenance Of Synapse Structure Structural Constituent Of Presynaptic Active Zone Maintenance Of Presynaptic Active Zone Structure Cell Junction Maintenance Presynaptic Active Zone Organization Cellular Component Maintenance Cytoskeleton Of Presynaptic Active Zone Synaptic Vesicle Exocytosis Presynaptic Active Zone Assembly Signal Release Organelle Localization Synapse Synaptic Vesicle Docking Presynaptic Active Zone Cytoplasmic Component Vesicle-mediated Transport In Synapse Synaptic Vesicle Clustering Regulated Exocytosis Vesicle Localization Secretion By Cell Presynapse Organization Axon Modulation Of Chemical Synaptic Transmission Secretion Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Exocytosis Organelle Glutamatergic Synapse Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Regulation Of Secretion Insulin Secretion Postsynaptic Density Regulation Of Synaptic Vesicle Exocytosis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Ovarian Follicle Rupture Structural Constituent Of Presynapse Vesicle Docking Epididymosome Protein Localization To Synapse Peptide Hormone Secretion Peptide Secretion Organelle Localization By Membrane Tethering
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