HOOK3 and CTIF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		HOOK3	CTIF
Description		hook microtubule tethering protein 3	cap binding complex dependent translation initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Cytoplasm Golgi Apparatus Cis-Golgi Network Centrosome Cytoskeleton Microtubule HOPS Complex Centriolar Satellite FHF Complex	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Dynactin Binding Identical Protein Binding Dynein Light Chain Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	RNA Binding Protein Binding Translation Activator Activity
	Biological Process	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Interkinetic Nuclear Migration Cytoskeleton-dependent Intracellular Transport Cytoplasmic Microtubule Organization Microtubule Anchoring At Centrosome Early Endosome To Late Endosome Transport Negative Regulation Of Neurogenesis Golgi Localization Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance Protein Localization To Perinuclear Region Of Cytoplasm	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Translation Regulation Of Translational Initiation Positive Regulation Of Translation
Pathways
Drugs
Diseases
GWAS		Zinc levels ( 26025379)	Automobile speeding propensity ( 30643258) Ceramide levels (C22:0) ( 32489964) Ceramide levels (C24:0) ( 32489964) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Iris heterochromicity ( 30895295) Large HDL particle concentration ( 29084231) Lumbar spine bone mineral density (integral) ( 27476799) Mean diameter of HDL particles ( 29084231) Phospholipid levels in large HDL ( 29084231) Red blood cell count ( 27863252 32888494) Response to carboplatin in ovarian cancer (MTT IC50) ( 27047539) Rheumatoid arthritis ( 30891314) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: AKTIP CTIF EIF4ENIF1 HOOK1 HOOK2 KRT13 MAPT MEOX2 PNMA5 VPS16 VPS41	8 interacting genes: ATPAF2 ATXN7L2 DCTN1 EEF1A1 HEXIM2 HOOK3 RECK SPG21
Entrez ID		84376	9811
HPRD ID		09699	11083
Ensembl ID		ENSG00000168172	ENSG00000134030
Uniprot IDs		Q86VS8	O43310
PDB IDs		5J8E 6B9H 8QAT 9KNS 9KO8
Enriched GO Terms of Interacting Partners?		HOPS Complex Endosome To Lysosome Transport FHF Complex Lysosomal Transport Protein Localization To Perinuclear Region Of Cytoplasm Vacuolar Transport Early Endosome To Late Endosome Transport Vesicle Organization Vacuole Organization Intracellular Transport Cytoplasmic Microtubule Organization Lysosome Organization Microtubule Binding Endosome Organization Endosomal Transport Cellular Localization Establishment Of Localization In Cell Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Transport Organelle Organization Establishment Of Protein Localization Dynein Light Intermediate Chain Binding Supramolecular Fiber Organization Cytoskeleton-dependent Intracellular Transport Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Microtubule Cytoskeleton Intracellular Protein Localization Vesicle-mediated Transport Neurofibrillary Tangle Assembly Clathrin-coated Vesicle Lysosomal HOPS Complex Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Vacuole Fusion, Non-autophagic Indoleamine 2,3-dioxygenase Activity Cytoplasmic Ribonucleoprotein Granule Microtubule Tryptophan 2,3-dioxygenase Activity Vesicle Fusion Actin Binding Organelle Membrane Fusion PML Body Vesicle Tethering Complex Regulation Of Translation Regulation Of Protein Metabolic Process Main Axon Negative Regulation Of Mitochondrial Fission	Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Microtubule Anchoring Nuclear Migration Nucleus Localization Response To Epidermal Growth Factor
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