CA8 and KLHL8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CA8	KLHL8
Description		carbonic anhydrase 8	kelch like family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Positive Regulation Of Calcium-mediated Signaling	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs		Zonisamide
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) High myopia ( 33830181) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 29483656 28991256 30285260 25056061) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33547301 33339817) Bulimia nervosa ( 23568457) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 28334899) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 30275531) Triglyceride levels ( 28334899 29403010 33339817) Triglycerides ( 20686565 25961943 24097068)
Interacting Genes		14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3	13 interacting genes: ARMC9 ATXN1 CA8 COIL MAPK9 PNMT PPM1F RAPSN RLBP1 SULT2B1 TEX101 TP53I13 USP7
Entrez ID		767	57563
HPRD ID		00266	13928
Ensembl ID		ENSG00000178538	ENSG00000145332
Uniprot IDs		P35219	B3KY78 Q68DU9 Q9P2G9
PDB IDs		2W2J
Enriched GO Terms of Interacting Partners?
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