DARS2 and ALDH18A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DARS2	ALDH18A1
Description		aspartyl-tRNA synthetase 2, mitochondrial	aldehyde dehydrogenase 18 family member A1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Membrane	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Membrane
	Molecular Function	TRNA Binding Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Nucleotide Binding RNA Binding Catalytic Activity Glutamate 5-kinase Activity Glutamate-5-semialdehyde Dehydrogenase Activity Protein Binding ATP Binding Kinase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Identical Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Glutamate Metabolic Process Ornithine Biosynthetic Process Amino Acid Biosynthetic Process Response To Temperature Stimulus Citrulline Biosynthetic Process L-proline Biosynthetic Process
Pathways		Mitochondrial tRNA aminoacylation	Mitochondrial protein degradation
Drugs		Aspartic acid	Glutamic acid
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Metabolite levels ( 23823483) PR interval ( 30046033 32439900) Staphylococcus aureus nasal carriage (persistent) ( 26569114)
Interacting Genes		16 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT CFTR COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	7 interacting genes: AGTRAP CDC42 CMTM5 COQ9 DARS2 RNF10 SYCE1L
Entrez ID		55157	5832
HPRD ID		07677	00696
Ensembl ID		ENSG00000117593	ENSG00000059573
Uniprot IDs		A0A3B3IT01 A0A3B3ITS3 Q6PI48 Q9H9J7	P54886
PDB IDs		4AH6	2H5G
Enriched GO Terms of Interacting Partners?		Aminoacyl-tRNA Synthetase Multienzyme Complex
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