DARS2 and FETUB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DARS2	FETUB
Description		aspartyl-tRNA synthetase 2, mitochondrial	fetuin B
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Membrane Mitochondrial Membrane	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding Nucleic Acid Binding Aminoacyl-tRNA Ligase Activity Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Aspartyl-tRNA Aminoacylation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation	Single Fertilization Binding Of Sperm To Zona Pellucida Negative Regulation Of Endopeptidase Activity Regulation Of Macromolecule Metabolic Process
Pathways		Mitochondrial tRNA aminoacylation
Drugs		Aspartic acid
Diseases		Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Activated partial thromboplastin time ( 22703881) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		16 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT CFTR COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50	8 interacting genes: CREB3L1 DARS2 EBP ERGIC3 HSD17B13 LMNA MTIF3 UBC
Entrez ID		55157	26998
HPRD ID		07677	09335
Ensembl ID		ENSG00000117593	ENSG00000090512
Uniprot IDs		A0A3B3IT01 A0A3B3ITS3 Q6PI48 Q9H9J7	B7Z8T3 E9PG08 Q5J875 Q9UGM5
PDB IDs		4AH6	6SAZ 7UAI
Enriched GO Terms of Interacting Partners?		Aminoacyl-tRNA Synthetase Multienzyme Complex	DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Membrane Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Steroid Delta-isomerase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER Aspartyl-tRNA Aminoacylation Aspartate-tRNA Ligase Activity Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Asparaginyl-tRNA Aminoacylation Extracellular Matrix Constituent Secretion Mitochondrial Translational Initiation Steroid Dehydrogenase Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Transporter Complex Lamin Filament Nuclear Pore Localization Endoplasmic Reticulum
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