NRDE2 and UQCC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NRDE2	UQCC2
Description		NRDE-2, necessary for RNA interference, domain containing	ubiquinol-cytochrome c reductase complex assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Speck	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Nuclear Body Mitochondrial Nucleoid
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle MRNA Processing DNA Damage Response RNA Splicing Regulatory NcRNA-mediated Heterochromatin Formation Positive Regulation Of RNA Export From Nucleus MRNA Stabilization Cell Division Negative Regulation Of RNA Catabolic Process	Regulation Of Oxidative Phosphorylation Mitochondrial Respiratory Chain Complex III Assembly Regulation Of Insulin Secretion Positive Regulation Of Mitochondrial Translation Regulation Of Skeletal Muscle Cell Differentiation
Pathways			Complex III assembly
Drugs
Diseases
GWAS		Lifespan ( 25918517) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Asthma and attention deficit hyperactivity disorder ( 31619474) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gait speed in old age ( 28077804) Hodgkin's lymphoma ( 30194254)
Interacting Genes		11 interacting genes: ARFIP2 CCDC183 HAUS8 ITGB3BP LHX3 MED29 MESD RCOR3 SPG21 UQCC2 VPS28	15 interacting genes: CDKN2D CEACAM5 EXOC8 GNG13 GRB2 HSPB1 MKRN3 MRFAP1 NRDE2 RABGAP1L SNAP25 TRAPPC2 TRAPPC2B TXN2 ZNF765
Entrez ID		55051	84300
HPRD ID		12625	12847
Ensembl ID		ENSG00000119720	ENSG00000137288
Uniprot IDs		Q9H7Z3	Q9BRT2
PDB IDs		6IEH
Enriched GO Terms of Interacting Partners?			Vesicle Tethering TRAPPII Protein Complex TRAPPIII Protein Complex TRAPP Complex Vesicle Organization COPII Vesicle Coating Perinuclear Region Of Cytoplasm Vesicle-mediated Transport Vesicle Coating Vesicle Docking Involved In Exocytosis Guanyl-nucleotide Exchange Factor Adaptor Activity Negative Regulation Of Protein Kinase C Signaling
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