MTRR and MMAB

Number of citations of the paper that reports this interaction (PubMedID 15347655)
0

Data Source:
HPRD (in vitro)

		MTRR	MMAB
Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase	metabolism of cobalamin associated B
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton	Mitochondrion Mitochondrial Matrix
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding Molecular Carrier Activity	Nucleotide Binding Protein Binding ATP Binding Corrinoid Adenosyltransferase Activity Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding
	Biological Process	Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process	Cobalamin Metabolic Process
Pathways		Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG Cobalamin (Cbl) metabolism	Defective MMAB causes MMA, cblB type Cobalamin (Cbl) metabolism
Drugs		Cyanocobalamin Methionine
Diseases		Spina bifida Homocystinuria	Methylmalonic aciduria (MMA)
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)	Age-related nuclear cataracts ( 33311586 24951543) Apolipoprotein A1 levels ( 32203549) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 19060906 25961943 20864672 20686565 18193043) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Monocyte percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: GMCL1 MMAB	2 interacting genes: CBY2 MTRR
Entrez ID		4552	326625
HPRD ID		03979	07398
Ensembl ID		ENSG00000124275	ENSG00000139428
Uniprot IDs		Q9UBK8	B4DHP4 Q96EY8
PDB IDs		2QTL 2QTZ	2IDX 6D5K 6D5X 7RUT 7RUU 7RUV
Enriched GO Terms of Interacting Partners?		Flavin-dependent Sulfhydryl Oxidase Activity Mitochondrial Disulfide Relay System Corrinoid Adenosyltransferase Activity Thiol Oxidase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Cobalamin Metabolic Process Protein-disulfide Reductase Activity	Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity NADPH-hemoprotein Reductase Activity S-adenosylmethionine Cycle Homocysteine Catabolic Process Methionine Biosynthetic Process FMN Binding Molecular Carrier Activity Sulfur Amino Acid Catabolic Process Homocysteine Metabolic Process Cobalamin Metabolic Process NADPH Binding Folic Acid Metabolic Process Sulfur Amino Acid Biosynthetic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Folic Acid-containing Compound Metabolic Process Pteridine-containing Compound Metabolic Process Sulfur Amino Acid Metabolic Process FAD Binding Aspartate Family Amino Acid Metabolic Process Intermediate Filament Cytoskeleton Tetrapyrrole Metabolic Process Amino Acid Biosynthetic Process Flavin Adenine Dinucleotide Binding Dicarboxylic Acid Metabolic Process Sulfur Compound Biosynthetic Process Amino Acid Catabolic Process Modified Amino Acid Metabolic Process L-amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Carboxylic Acid Catabolic Process Sulfur Compound Metabolic Process Carboxylic Acid Biosynthetic Process Amino Acid Metabolic Process
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