MCCD1 and KYNU

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCCD1	KYNU
Description		mitochondrial coiled-coil domain 1	kynureninase
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Pyridoxal Phosphate Binding Kynureninase Activity Protein Homodimerization Activity
	Biological Process		L-tryptophan Catabolic Process Nucleoside Phosphate Metabolic Process NAD+ Biosynthetic Process Pyridine Nucleotide Biosynthetic Process L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Type II Interferon 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Response To Vitamin B6 Anthranilate Metabolic Process Purine-containing Compound Metabolic Process L-kynurenine Catabolic Process
Pathways			Tryptophan catabolism
Drugs			Pyridoxal phosphate Alanine m-Hydroxyhippuric acid
Diseases
GWAS		AIDS progression ( 19115949) Asthma ( 29273806 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Cervical cancer ( 28806749) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Malaria ( 31844061) Ulcerative colitis ( 28067908)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma and eczema ( 34155719) Blood protein levels ( 30072576) Cataracts ( 34127677) Empathy quotient ( 29527006) Glomerular filtration rate in chronic kidney disease ( 26420894) Neurological blood protein biomarker levels ( 31320639) Platelet count ( 32888494) Response to SSRI (symptom remission) ( 29160301) Toenail selenium levels ( 25343990)
Interacting Genes		26 interacting genes: BEX3 BFSP2 CAB39 COX5B FNDC3B KANK2 KRT26 KYNU LMO4 LSM1 MEIS2 MGAT5B MKRN3 MX1 MYL7 P4HA3 PIH1D2 PPP1R16A PRR35 QARS1 RIPPLY1 USHBP1 USP20 ZNF417 ZNF587 ZNF765	9 interacting genes: CDC42 CT55 CTBP2 FAM86C1P LMO4 MCCD1 MYOZ3 PIP4K2B RASSF3
Entrez ID		401250	8942
HPRD ID		17470	08940
Ensembl ID		ENSG00000204511	ENSG00000115919
Uniprot IDs		A0A1U9X802 P59942	Q16719 Q53SX6
PDB IDs			2HZP 3E9K 7S3V
Enriched GO Terms of Interacting Partners?
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