SMYD1 and MYH7B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid)

		SMYD1	MYH7B
Description		SET and MYND domain containing 1	myosin heavy chain 7B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Membrane Myosin Complex Myosin II Complex Myofibril Myosin Filament Cardiac Myofibril
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone H3K4 Methyltransferase Activity Metal Ion Binding Histone H3K4 Trimethyltransferase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding ATP Binding Actin Filament Binding
	Biological Process	Chromatin Remodeling Heart Development Positive Regulation Of Myotube Differentiation Methylation Skeletal Muscle Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription	Regulation Of Calcium-mediated Signaling Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cardiac Muscle Cell Contraction Regulation Of CAMKK-AMPK Signaling Cascade
Pathways		Cardiogenesis
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917) Retinal detachment or retinal break ( 31816047)	Alanine aminotransferase levels ( 34315874) Anticoagulant levels ( 22216198) Aspartate aminotransferase levels ( 34315874 33547301) Bipolar disorder ( 31043756) Birth weight ( 31043758) Congenital left-sided heart lesions ( 26965164) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Melanoma ( 28212542) Offspring birth weight ( 31043758) Prothrombin time ( 22703881) QRS complex (Cornell) ( 27659466) QRS duration ( 30012220) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: ARID5A BACH2 BHLHE40 C11orf16 CCDC33 CFAP263 CFAP68 CFTR CIMIP2A DISC1 DVL1 FAM204A FAM83A FAM86C1P H3-5 HDAC2 HDAC3 HDHD3 HMG20A HOMEZ KIF16B KRT35 LENG8 MDFI MEOX2 MYH7B NACA NEFL OGDHL PATZ1 POU2AF2 POU6F2 PRR22 RBM4B RSPH6A RUSC1 SNX11 SPAG8 TBRG1 TTC33 USP54 UTP14A WDR77 ZBTB3 ZBTB44	8 interacting genes: ETFDH FOXP1 PITX1 QRICH1 RBPMS SMYD1 TLE5 TNS2
Entrez ID		150572	57644
HPRD ID		06025	11379
Ensembl ID		ENSG00000115593	ENSG00000078814
Uniprot IDs		E9PHG3 Q8NB12	A7E2Y1
PDB IDs
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Axonemal A Tubule Inner Sheath Microtubule-based Process Regulation Of Transcription By RNA Polymerase II Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sperm Flagellum Cilium Movement Involved In Cell Motility Circadian Rhythm Protein Lysine Deacetylase Activity Microtubule-based Movement
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