YAF2 and SETBP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		YAF2	SETBP1
Description		YY1 associated factor 2	SET binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytosol Nuclear Body
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding Histone H3K4 Methyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription	Chromatin Remodeling Regulation Of DNA-templated Transcription
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs
Diseases			Schinzel-Giedion midface retraction syndrome
GWAS		Refractive error ( 32231278)	Adult body size ( 32376654) Bone ultrasound measurement (velocity of sound) ( 28472463) Breast cancer ( 29059683 25751625 31757997) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Coronary artery aneurysm in Kawasaki disease ( 27171184) Diastolic blood pressure ( 27618452) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Estimated glomerular filtration rate ( 31152163) Hair color ( 26926045) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 22693459 29146897 28196072) Mean platelet volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Neonatal white matter microstructure ( 33009551) Number of sexual partners ( 30643258) Platelet thrombus formation ( 22550155) Pulse pressure ( 27841878) QRS duration ( 30012220 30679814 27577874 25035420 27659466) QRS interval (sulfonylurea treatment interaction) ( 27958378) Refractive error ( 32231278) Restless legs syndrome ( 29029846) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 28739976 27618452 27841878) Waist circumference ( 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		28 interacting genes: ANP32B CAVIN1 CD300LF DNAAF6 EAF1 GABPB1 IFT57 INO80B LGALS7 LGALS7B MAPRE3 MARK1 MYC MYCN NEDD8 NUTF2 PCDH17 POLR3GL PPP1R11 PTEN SETBP1 SPANXN2 SPANXN3 TLK1 UBC XAGE1B YY1 ZFP42	13 interacting genes: APP DENND11 LRRC37A11P PLEKHF2 SET SPANXA1 SPANXA2 SPANXC SPANXD SUMO1P1 UBE2I XAGE1B YAF2
Entrez ID		10138	26040
HPRD ID		09606	10224
Ensembl ID		ENSG00000015153	ENSG00000152217
Uniprot IDs		B4DJQ9 G3V212 Q8IY57	A0A7I2V4X1 Q9Y6X0
PDB IDs		2D9G
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of MiRNA Transcription Positive Regulation Of Telomere Maintenance Protein Tag Activity Regulation Of Synaptic Vesicle Clustering Regulation Of DNA Strand Elongation Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Chromatin Organization Regulation Of MiRNA Metabolic Process
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