SH2B3

Description		SH2B adaptor protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Stem Cell Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Neutrophil Homeostasis Myeloid Cell Homeostasis Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Population Proliferation Hemopoiesis Embryonic Hemopoiesis Intracellular Signal Transduction Monocyte Homeostasis Megakaryocyte Development Cellular Response To Interleukin-3 Thrombopoietin-mediated Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Erythrocyte Development Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hematopoietic Stem Cell Differentiation Negative Regulation Of Response To Cytokine Stimulus Myeloid Cell Development Negative Regulation Of Chemokine-mediated Signaling Pathway Negative Regulation Of Platelet Aggregation Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT Cellular Response To Chemokine
Pathways		Regulation of KIT signaling Negative regulation of FLT3 Factors involved in megakaryocyte development and platelet production
Drugs		Pazopanib
Diseases		Type I diabetes mellitus
GWAS		Addison's disease ( 33574239) Alanine aminotransferase levels ( 33547301 34315874) Allergic rhinitis ( 30013184) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autoimmune hepatitis type-1 ( 24768677) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Body mass index ( 26426971 29273807) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Celiac disease ( 18311140 20190752 22057235 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 24262325 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 19430479 19430483 21909115 26390057 27618447 27618452 27736895 27841878 28739976 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Eosinophil count ( 19198610 32888494) Fibrinogen levels ( 26561523 28107422) Gastroesophageal reflux disease ( 31527586) Glaucoma (multi-trait analysis) ( 31959993) Glycated hemoglobin levels ( 34059833) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 19862010 27863252 28017375 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) IgA levels ( 28628107) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 31959993) Ischemic stroke ( 24262325) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Left ventricular end-diastolic volume ( 32382064 33495596) Left ventricular end-systolic volume ( 33495596) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte count ( 27863252 32888494) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252 28017375) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 28017375) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 26343387) Neutrophil count ( 27863252 32888494) Offspring birth weight ( 31043758) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 20139978 22139419 24026423 25705162 27863252 32888494 33545615) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763 27992413) Reaction time ( 27046643) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Retinal vascular caliber ( 21060863) Rheumatoid arthritis ( 24390342 30423114 32723749) Sarcoidosis ( 26051272) Small vessel stroke (CCS or TOAST classification) ( 32047268) Small vessel stroke (CCSp classification) ( 32047268) Spleen volume ( 34128465) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966) Systolic blood pressure ( 19430479 27618452 27841878 28739976 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Thyroid stimulating hormone levels ( 32769997) Tonsillectomy ( 27182965 28928442) Tumor necrosis factor levels ( 32805626) Type 1 diabetes ( 17554300 19430480 21829393 25751624 30572963) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 32499647) Vitiligo ( 22561518 27723757) White blood cell count ( 27863252 32888494)
Novel Interacting Genes		3 novel interacting genes: BRAP NCOR2 VPS29
Interacting Genes		12 interacting genes: CD247 EGFR ERBB2 ERBB3 ERBB4 FLNA GRB2 KIT LCK MET TNS2 ZAP70
Entrez ID		10019
HPRD ID		05480
Ensembl ID		ENSG00000111252
Uniprot IDs		B7Z7K6 F5GYM4 Q59H48 Q96BA5 Q9UQQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Kinase Activity ERBB2 Signaling Pathway ERBB Signaling Pathway Receptor Complex Regulation Of Signal Transduction Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Peptidyl-tyrosine Phosphorylation T Cell Activation Schwann Cell Development Cell-cell Junction ERBB3:ERBB2 Complex Protein Phosphatase Binding Lymphocyte Activation Positive Regulation Of Intracellular Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Transferase Activity Identical Protein Binding Cell Development Leukocyte Activation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation ATP Binding ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Semaphorin-plexin Signaling Pathway Antigen Receptor-mediated Signaling Pathway Growth Factor Binding Protein Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Phosphotyrosine Residue Binding Neuron Differentiation Regulation Of Programmed Cell Death Cell Activation Signal Transduction Response To Epidermal Growth Factor Phosphorylation
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