NR3C2

Description		nuclear receptor subfamily 3 group C member 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Receptor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Hormone Stimulus Response To Lipid Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors
Drugs		Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Stanolone acetate Finerenone
Diseases		Hypertension exacerbated in pregnancy Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Microalbuminuria ( 31511532) Neutrophil percentage of white cells ( 32888494) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet distribution width ( 32888494) Platelet reactivity in response to clopidogrel treatment ( 32472697) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)
Novel Interacting Genes		20 novel interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I
Interacting Genes		20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I
Entrez ID		4306
HPRD ID		02991
Ensembl ID		ENSG00000151623
Uniprot IDs		B0ZBF6 P08235
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG 6L88
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Estrogen Response Element Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Transcription Factor Binding SUMO Transferase Activity Regulation Of Macromolecule Biosynthetic Process Chaperone-mediated Protein Complex Assembly Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cytoplasm Negative Regulation Of Transcription By RNA Polymerase II PML Body DNA Binding Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Small Protein Activating Enzyme Binding Chromatin Nucleus Skeletal Muscle Thin Filament Assembly Transcription By RNA Polymerase II Telomerase Holoenzyme Complex Assembly Nuclear Receptor Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Estrogen Regulation Of Vitamin D Receptor Signaling Pathway Cytosol
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