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DOK1
Description
docking protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Binding
Biological Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Ras Protein Signal Transduction
Intracellular Signal Transduction
Macrophage Colony-stimulating Factor Signaling Pathway
Pathways
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling
Drugs
Diseases
GWAS
Bell's palsy (
33602968
)
Height (
31562340
)
Novel Interacting Genes
42 novel interacting genes:
ABL1
ABL2
BCR
CRK
CRKL
CSDE1
CSK
DOK3
ERBB2
FES
FGR
FYN
GRB10
HCK
INPP5D
INSR
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
ITK
KIT
LCK
LYN
MAP4K4
NCK1
NCK2
PIK3R1
PLCG1
PTK6
PTPN6
PTPRH
RASA1
RET
SH2D1A
SHC1
SRC
TEC
TLN1
VAV1
YES1
Interacting Genes
42 interacting genes:
ABL1
ABL2
BCR
CRK
CRKL
CSDE1
CSK
DOK3
ERBB2
FES
FGR
FYN
GRB10
HCK
INPP5D
INSR
ITGB1
ITGB2
ITGB3
ITGB5
ITGB7
ITK
KIT
LCK
LYN
MAP4K4
NCK1
NCK2
PIK3R1
PLCG1
PTK6
PTPN6
PTPRH
RASA1
RET
SH2D1A
SHC1
SRC
TEC
TLN1
VAV1
YES1
Entrez ID
1796
HPRD ID
04228
Ensembl ID
ENSG00000115325
Uniprot IDs
B3KP83
B4DJN1
Q14CB2
Q2TA81
Q99704
PDB IDs
2V76
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Phosphotyrosine Residue Binding
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Cell Migration
Regulation Of Cell Adhesion
Regulation Of Immune System Process
Peptidyl-tyrosine Phosphorylation
Fc Receptor Signaling Pathway
Cell Motility
Positive Regulation Of Cell Adhesion
Immune Response-regulating Signaling Pathway
Protein Kinase Activity
Regulation Of Immune Response
Protein Phosphorylation
Kinase Activity
Immune Response-activating Signaling Pathway
Plasma Membrane
Leukocyte Migration
Integrin-mediated Signaling Pathway
Phosphorylation
Immune System Process
Activation Of Immune Response
Fc-gamma Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Immune Response
Fc Receptor Mediated Stimulatory Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
T Cell Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Immune System Process
Cell Activation
Positive Regulation Of Leukocyte Cell-cell Adhesion
Leukocyte Activation
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
T Cell Costimulation
Regulation Of Leukocyte Cell-cell Adhesion
Immune Effector Process
Regulation Of Signal Transduction
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