MTRR

Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADPH Binding FAD Binding Molecular Carrier Activity
	Biological Process	Amino Acid Biosynthetic Process Methionine Biosynthetic Process Cobalamin Metabolic Process S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process
Pathways		Methylation Sulfur amino acid metabolism Defective MTRR causes HMAE Defective MTR causes HMAG Cobalamin (Cbl) metabolism
Drugs		Cyanocobalamin Methionine
Diseases		Spina bifida Homocystinuria
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Novel Interacting Genes		1 novel interacting genes: GFER
Interacting Genes		2 interacting genes: GMCL1 MMAB
Entrez ID		4552
HPRD ID		03979
Ensembl ID		ENSG00000124275
Uniprot IDs		Q9UBK8
PDB IDs		2QTL 2QTZ
Enriched GO Terms of Interacting Partners?		Flavin-dependent Sulfhydryl Oxidase Activity Mitochondrial Disulfide Relay System Corrinoid Adenosyltransferase Activity Thiol Oxidase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Cobalamin Binding Cobalamin Metabolic Process Protein-disulfide Reductase Activity
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