Alzheimer - Wiki-Pi

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APP and NUAK1	amyloid beta (A4) precursor protein	NUAK family, SNF1-like kinase, 1	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and VAT1L	amyloid beta (A4) precursor protein	vesicle amine transport 1-like	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and SPON1	amyloid beta (A4) precursor protein	spondin 1, extracellular matrix protein	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Post-translational protein modification O-glycosylation of TSR domain-containing proteins O-linked glycosylation
APP and TSPAN13	amyloid beta (A4) precursor protein	tetraspanin 13	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and ITGA6	amyloid beta (A4) precursor protein	integrin, alpha 6	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Cell junction organization Syndecan interactions Type I hemidesmosome assembly Collagen formation Laminin interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions Assembly of collagen fibrils and other multimeric structures Basigin interactions Cell surface interactions at the vascular wall
APP and MMP12	amyloid beta (A4) precursor protein	matrix metallopeptidase 12 (macrophage elastase)	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Collagen degradation Degradation of the extracellular matrix		Acetohydroxamic Acid Marimastat CP-271485 PF-00356231 Batimastat 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4\'-Ethoxy-1,1\'-Biphenyl-4-Yl)-4-Oxobutanoic Acid (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE N-(biphenyl-4-ylsulfonyl)-D-leucine N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide N-oxo-2-(phenylsulfonylamino)ethanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[(4-methoxyphenyl)sulfonyl]-D-alanine
APP and MOBP	amyloid beta (A4) precursor protein	myelin-associated oligodendrocyte basic protein	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and MRPL10	amyloid beta (A4) precursor protein	mitochondrial ribosomal protein L10	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination
APP and PSEN2	amyloid beta (A4) precursor protein	presenilin 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Signaling by NOTCH1 HD Domain Mutants in Cancer Axon guidance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 EPH-ephrin mediated repulsion of cells Signaling by NOTCH1 EPH-Ephrin signaling Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signaling by NOTCH4 Regulated proteolysis of p75NTR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by NOTCH p75 NTR receptor-mediated signalling Signaling by ERBB4 NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Nuclear signaling by ERBB4 NRIF signals cell death from the nucleus Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH3 Constitutive Signaling by NOTCH1 PEST Domain Mutants
APP and PSMA1	amyloid beta (A4) precursor protein	proteasome (prosome, macropain) subunit, alpha type, 1	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
APP and TTLL7	amyloid beta (A4) precursor protein	tubulin tyrosine ligase-like family member 7	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and LIMS2	amyloid beta (A4) precursor protein	LIM and senescent cell antigen-like domains 2	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Cell junction organization Cell-extracellular matrix interactions
APP and SLC4A1AP	amyloid beta (A4) precursor protein	solute carrier family 4 (anion exchanger), member 1, adaptor protein	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation
APP and STK11	amyloid beta (A4) precursor protein	serine/threonine kinase 11	Signaling by GPCR Platelet degranulation Metabolic disorders of biological oxidation enzymes RIP-mediated NFkB activation via ZBP1 Formyl peptide receptors bind formyl peptides and many other ligands Amyloids Toll Like Receptor TLR1:TLR2 Cascade Peptide ligand-binding receptors Toll Like Receptor 5 (TLR5) Cascade The NLRP3 inflammasome Gastrin-CREB signalling pathway via PKC and MAPK Response to elevated platelet cytosolic Ca2+ MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade G alpha (i) signalling events TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade G alpha (q) signalling events GPCR downstream signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Platelet activation, signaling and aggregation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Class A/1 (Rhodopsin-like receptors) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Activated TLR4 signalling MyD88 cascade initiated on plasma membrane ZBP1(DAI) mediated induction of type I IFNs ECM proteoglycans MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Advanced glycosylation endproduct receptor signaling Innate Immune System Inflammasomes Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade GPCR ligand binding Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TRAF6 mediated NF-kB activation	Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
CLU and VLDLR	clusterin	very low density lipoprotein receptor	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
CLU and DISC1	clusterin	disrupted in schizophrenia 1	Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
PIK3R1 and PSEN1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	presenilin 1	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade	Degradation of the extracellular matrix	Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
PIK3R1 and CD2AP	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	CD2-associated protein	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade	Nephrin interactions	Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
PIK3R1 and GAB2	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	GRB2-associated binding protein 2	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade	Signaling by GPCR Signaling by FGFR in disease G-protein beta:gamma signalling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by SCF-KIT Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Signaling by FGFR1 mutants Interleukin receptor SHC signaling Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants GPVI-mediated activation cascade Interleukin-2 signaling Signaling by FGFR1 fusion mutants Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Innate Immune System	Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
PIK3R1 and RRAS2	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	related RAS viral (r-ras) oncogene homolog 2	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Signaling by FGFR1 mutants Interleukin-7 signaling Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling G alpha (q) signalling events Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling Signaling by Interleukins TCR signaling Signaling by VEGF GP1b-IX-V activation signalling Downstream signal transduction Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Downstream TCR signaling Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events Antigen activates B Cell Receptor (BCR) leading to generation of second messengers PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer IRS-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling Signaling by FGFR1 fusion mutants Constitutive Signaling by EGFRvIII PI3K Cascade		Isoproterenol (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE

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