CISD1 and BICC1

		CISD1	BICC1
Description		CDGSH iron sulfur domain 1	BicC family RNA binding protein 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane	Cytoplasm
	Molecular Function	Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding L-cysteine Transaminase Activity Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Nucleic Acid Binding RNA Binding
	Biological Process	Intracellular Iron Ion Homeostasis Regulation Of Autophagy Regulation Of Cellular Respiration Protein Maturation	Kidney Development Determination Of Left/right Symmetry Heart Development Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908)	Blood urea nitrogen levels ( 31152163 29403010) Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 33627673) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Intraocular pressure ( 31959993) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Manganese levels ( 26025379) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Midgestational circulating levels of PCBs ( 28235828) Morning person ( 30696823) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278 23396134) Serum uric acid levels ( 30993211 29403010) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Urate levels ( 31985003 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		1 interacting genes: SNRPA	4 interacting genes: GABARAP GABARAPL1 GABARAPL2 MAP1LC3C
Entrez ID		55847	80114
HPRD ID		12587	18993
Ensembl ID		ENSG00000122873	ENSG00000122870
Uniprot IDs		Q9NZ45	Q9H694
PDB IDs		2QD0 2QH7 2R13 3EW0 3LPQ 3REE 4EZF 4F1E 4F28 4F2C 6DE9 7P0O	4RQM 4RQN 6GY4
Enriched GO Terms of Interacting Partners?		U1 SnRNA Binding Spliceosomal SnRNP Complex Nucleic Acid Binding U1 SnRNP Binding U1 SnRNP U4/U6 X U5 Tri-snRNP Complex	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly GABA Receptor Binding Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Beta-tubulin Binding Response To Starvation Cellular Response To Nutrient Levels Autophagy Ubiquitin Protein Ligase Binding Response To Nutrient Levels Organelle Assembly Cytoplasmic Vesicle Microtubule Protein-containing Complex Organization L-cysteine Transaminase Activity Cellular Response To Stress Positive Regulation Of Protein K48-linked Ubiquitination Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein K48-linked Ubiquitination Microtubule Binding Endomembrane System Tat Protein Binding Protein Transport Glycophagy Cellular Component Assembly Aggrephagy Organelle Organization Protein Localization To Endoplasmic Reticulum Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Polyubiquitination Establishment Of Protein Localization Regulation Of Protein Catabolic Process Smooth Endoplasmic Reticulum Regulation Of Proteolysis Positive Regulation Of ATP-dependent Activity Glycogen Catabolic Process Golgi Apparatus Polysaccharide Catabolic Process
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